Core--Natural Products

核心--天然产物

• 批准号: 6666477
• 负责人: ABIMAEL D RODRIGUEZ
• 金额: $ 14.82万
• 依托单位: UNIVERSIDAD CENTRAL DEL CARIBE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6666477
• 关键词: animal extract; biological products; biomedical facility; chemical synthesis; conformation; coral; diterpenes; marine biology; plant extracts

Since cembranoids are not commercially available, it is necessary to obtain them from their natural sources: soft corals found in the tropical seas around Puerto Rico, or from tobacco. The Natural Products Core is a unique CMBN facility that will became a part of the SNRP to provide the cembranoids needed in Projects 1 and 2. This core will organize diving expeditions for collections of specimens, will isolate the compounds to high purity, prepare custom-tailored synthetic analogues, determine their molecular structures, and calculates energy-minimized three-dimensional conformations.

由于西松烷类化合物无法在商业上获得，因此有必要从其天然来源中获取它们：波多黎各周围热带海洋中发现的软珊瑚，或从烟草中获取。天然产品核心是一个独特的 CMBN 设施，将成为 SNRP 的一部分，以提供项目 1 和 2 所需的西松烷类化合物。该核心将组织潜水探险以收集标本，将化合物分离到高纯度，制备定制的合成类似物，确定其分子结构，并计算能量最小化的三维构象。