CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
基本信息
- 批准号:6472788
- 负责人:
- 金额:$ 11.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2002-06-30
- 项目状态:已结题
- 来源:
- 关键词:Caribbean islands X ray crystallography animal extract antitubercular agents aquatic organism biological products chemical structure function coral drug discovery /isolation drug screening /evaluation field study gas chromatography infrared spectrometry laboratory mouse liquid chromatography mass spectrometry nuclear magnetic resonance spectroscopy saltwater environment ultraviolet spectrometry
项目摘要
Description (Adapted from Application): Marine invertebrates have been
identified for a long time by chemists as likely sources of new biomedicinal
substances. Pharmacologists, physiologists, and biochemists have demonstrated
that many of these novel marine products modify fundamental life processes in
ways suggesting biomedical applications. These molecules can serve as leads to
guide the pharmaceutical and chemical industries in developing new products.
This research aims specifically at Caribbean gorgonian octocorals as a likely
resource for novel anti-tuberculosis natural products. Since less than 20
percent of the species of gorgonian octocorals known to exist in the Caribbean
region have been assessed chemically for their secondary metabolite
composition, and many of these have been shown to produce metabolites
possessing potent chemotherapeutic properties, gorgonians from this region have
the potential to contain a wealth of novel drugs. Specifically, during the four
years of this research, the investigators plan to carefully scrutinize the
pharmacology and chemistry of 40 or so representative species belonging to all
the major Caribbean gorgonian genera. Initial extraction with solvents of
different polarities (e.g., hexane, methylene chloride, and methanol) will be
monitored using anti-tuberculosis activity assays. Only gorgonian extract
residues possessing strong anti-tuberculosis properties will be screened
further for chemical structural features by 1H- and 13C-NMR spectroscopy.
Further purification by chromatography (column, GC, LC) and determination of
molecular structure will proceed if warranted by the screening results.
Structure elucidation will rely heavily on spectral methods (e.g., 1H- and
13C-NMR, MS, IR, UV) and X-ray diffraction techniques.
描述(改编自应用):海洋无脊椎动物已被
化学家们长期以来认为它是新生物医学的可能来源。
物质.药理学家生理学家和生物化学家已经证明
许多这些新的海洋产品改变了基本的生命过程,
建议生物医学应用的方式。这些分子可以作为
指导医药化工行业开发新产品。
这项研究专门针对加勒比海柳珊瑚,
是一种新型抗结核天然产物资源。由于不到20
已知存在于加勒比海的柳珊瑚物种的百分比
已对其次级代谢产物进行了化学评估
组成,其中许多已被证明可以产生代谢物
拥有强大的化疗特性,来自这个地区的柳珊瑚
蕴藏着大量新药的潜力具体来说,在四
经过多年的研究,研究人员计划仔细检查
药理学和化学的40左右的代表性物种属于所有
加勒比海柳珊瑚的主要属。初始浸提溶剂为
不同的极性(例如,己烷、二氯甲烷和甲醇),
使用抗结核活性测定进行监测。只有柳珊瑚提取物
将筛选具有强抗结核特性的残基
进一步通过1H-和13 C-NMR光谱分析化学结构特征。
通过色谱法(柱,GC,LC)进一步纯化并测定
如果筛选结果有必要,将继续进行分子结构分析。
结构解析将严重依赖于光谱方法(例如,1H-和
13 C-NMR、MS、IR、UV)和X射线衍射技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ABIMAEL D RODRIGUEZ', 18)}}的其他基金
Anti-tuberculosis Agents from Gorgonian Octocorals
柳珊瑚八珊瑚的抗结核剂
- 批准号:
6766444 - 财政年份:2004
- 资助金额:
$ 11.03万 - 项目类别:
CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
- 批准号:
6601184 - 财政年份:2002
- 资助金额:
$ 11.03万 - 项目类别:
CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
- 批准号:
6609860 - 财政年份:2002
- 资助金额:
$ 11.03万 - 项目类别:
CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
- 批准号:
6631251 - 财政年份:2002
- 资助金额:
$ 11.03万 - 项目类别:
CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
- 批准号:
6564512 - 财政年份:2002
- 资助金额:
$ 11.03万 - 项目类别:
CARIBBEAN OCTOCORAL--SOURCE FOR ANTITUBERCULAR COMPOUNDS
加勒比八珊瑚——抗结核化合物的来源
- 批准号:
6325851 - 财政年份:2000
- 资助金额:
$ 11.03万 - 项目类别:
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