CORE--ANIMAL

核心--动物

• 批准号: 6112512
• 负责人: Chung Y. Hsu
• 金额: $ 14.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6112512
• 关键词: animal care; biomedical facility; blood flow measurement; brain disorder chemotherapy; cerebral ischemia /hypoxia; disease /disorder model; drug screening /evaluation; histopathology; laboratory rat; microdialysis; neural degeneration; neuroprotectants; nonhuman therapy evaluation; stroke

Core B provided technical support to conducts in vivo experiments employing animal stroke models proposed in Projects I, II, and IV in this program project (PPG). The main function of Core B can be divided into three areas: (1) to establish and maintain a focal ischemia model and a global ischemia model for in vivo studies within the PPG; (2) to implement and execute in vivo experimental protocols designed by PPG investigators; and (3) to conduct preclinical trials when promising new drugs are identified in this PPG. The overall objectives of Core B are to confirm important in vitro findings in in vivo systems and to facilitate new drug development.

核心B为进行活体实验提供技术支持 使用本项目I、II和IV中提出的动物中风模型 计划项目(PPG)。核心B的主要功能可以分为 三个方面：(1)建立并维持大鼠局灶性脑缺血模型； 用于PPG体内研究的全球缺血模型；(2) 实施和执行PPG设计的体内实验方案 研究人员；以及(3)在有希望的情况下进行临床前试验 药物是在这个PPG中识别的。核心B的总体目标是 在体内系统中确认重要的体外研究结果，并 促进新药开发。