Core--Injury and functional assessment

核心--损伤和功能评估

• 批准号: 6326697
• 负责人: Chung Y. Hsu
• 金额: $ 17.53万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-17 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326697
• 关键词: animal care; biomedical facility; functional ability; laboratory mouse; laboratory rat; spinal cord injury

DESCRIPTION: (Abstract used): This Core will provide technical support for in vivo experiments proposed in the PPG. The Core will apply rat and mouse models of spinal cord injury (SCI) using an NYU Impactor to assist in the conduction of in vivo studies proposed in Projects 3 and 4. The majors goals of Core C are to establish and maintain rodent SCI models for animals studies; to implement and execute in vivo experimental protocol proposed by PPG investigators; and to assess changes in functional outcomes following interventions administered by PPG investigators. The overall objective of this Core is to support PPG investigators in conducting in vivo experiments and in determining the efficacy of ES cell transplantation for improving functional recovery after SCI.

（摘要使用）：本核心将为PPG中提出的体内实验提供技术支持。核心将使用NYU冲击器应用大鼠和小鼠脊髓损伤模型来协助项目3和4中提出的体内研究的进行。Core C的主要目标是建立和维护用于动物研究的啮齿动物SCI模型；实施和执行PPG研究者提出的体内实验方案；并评估PPG研究人员实施干预后功能结果的变化。该核心的总体目标是支持PPG研究人员进行体内实验，并确定胚胎干细胞移植对改善脊髓损伤后功能恢复的功效。