Dopamine neuron ontogeny: convergent neurobiological pathway for risk factors of schizophrenia

多巴胺神经元个体发育：精神分裂症危险因素的汇聚神经生物学途径

• 批准号: nhmrc : 1139960
• 金额: $ 22.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dopamine-neuron-ontogeny-factors-schizophrenia/1319137
• 关键词: Dopamine; neuron; ontogeny; convergent; neurobiological

Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.

精神分裂症与多巴胺（大脑中的信号分子）的变化有关。这些变化出现在精神病之前，表明它们在发育的早期就开始开始。我们的目标是操纵大脑多巴胺系统发展中的关键因素，以澄清它们在精神病和精神分裂症中的作用。这项工作有可能识别导致精神分裂症的早期大脑变化，这反过来可能会为患有这种疾病的人产生更好的诊断和结果。