BACKGROUND EXPOSURE TO STYRENE & STYRENE OXIDE

背景接触苯乙烯

• 批准号: 6297265
• 负责人: STEPHEN J RAPPAPORT
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297265
• 关键词: DNA damage; adduct; chemical carcinogen; clinical chemistry; clinical research; cycloalkene; dosage; environmental toxicology; human subject; occupational hazard; plastics

Preliminary evidence shows that exposure to the carcinogen, styrene-7, 8-oxide (SO) which arises from reactions of styrene during the production of reinforced plastics and from metabolism of styrene, causes significant increases of SO biomarkers in workers. Biomarkers are the adducts of SO with DNA and serum albumin and sister chromatid exchanges. The proposed study is intended to determine the relative contributions of inhaled styrene and SO to the dose of SO in the blood of workers in the reinforced plastics industry. Part one of this project involves recruitment of 100 workers within 17 sites in the reinforced plastics industry. A measurement of airborne exposure of styrene and SO for each worker twice during one year will be done as well as collection of blood samples. This project is being submitted to the Committee for the Protection of the Rights of Human Subjects and the GCRC in order to complete one of the secondary objectives: to determine whether SO per se is the source of background adducts of SO in human blood by using ultratrace analyses of SO in the blood of 100 persons without occupational exposures to styrene or SO. Protein and DNA adducts will also be measured in these persons to allow comparison of background adduct levels with those of SO in the blood.

初步证据表明，接触致癌物质苯乙烯-7, 8-氧化物 (SO)（由增强塑料生产过程中苯乙烯反应和苯乙烯代谢产生）会导致工人体内 SO 生物标志物显着增加。 生物标志物是 SO 与 DNA 和血清白蛋白以及姐妹染色单体交换的加合物。 拟议的研究旨在确定吸入苯乙烯和二氧化硫对增强塑料行业工人血液中二氧化硫剂量的相对贡献。 该项目的第一部分涉及在增强塑料行业的 17 个地点招聘 100 名工人。 一年内将对每位工人进行两次空气中苯乙烯和二氧化硫暴露量测量，并采集血液样本。 该项目正在提交给人类受试者权利保护委员会和 GCRC，以完成次要目标之一：通过对 100 名没有职业接触苯乙烯或 SO 的人的血液中 SO 进行超痕量分析，确定 SO 本身是否是人类血液中 SO 背景加合物的来源。 还将测量这些人的蛋白质和 DNA 加合物，以便将背景加合物水平与血液中的 SO 水平进行比较。