BACKGROUND EXPOSURE TO STYRENE & STYRENE OXIDE

背景接触苯乙烯

• 批准号: 6303937
• 负责人: STEPHEN J RAPPAPORT
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303937
• 关键词: DNA damage; adduct; chemical carcinogen; clinical chemistry; clinical research; cycloalkene; dosage; environmental toxicology; human subject; occupational hazard; plastics

The purpose of this study is to measure styrene, stryene oxide, benzene, benzene oxide or their products in the blood. Workers in the reinforced plastics industry are exposed to relatively large amounts of styrene and petroleum workers are exposed to relatively large amounts of benzene. We are conducting other studies of such workers to determine how much of these chemicals are in their blood. Because small amounts of styrene, styrene oxide, benzene and benzene oxide may be present in everyday life, in foods for example, we also want to determine the natural background levels of these substances in the blood of people without occupational exposure to styrene and benzene. We would also like to determine if these low background levels are related to DNA damage in the blood and how well the blood metabolizes these chemicals.

本研究的目的是测量血液中的苯乙烯、环氧乙烯、苯、氧化苯或其产物。增强塑料工业的工人接触到相对大量的苯乙烯，石油工人接触到相对大量的苯。我们正在对这些工人进行其他研究，以确定他们血液中这些化学物质的含量。因为在日常生活中，比如食物中可能存在少量苯乙烯、苯乙烯氧化物、苯和氧化苯，我们还想确定没有职业接触苯乙烯和苯的人血液中这些物质的自然背景水平。我们还想确定这些低背景水平是否与血液中的DNA损伤有关，以及血液如何代谢这些化学物质。