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STUDY TO EVALUATE THE RENAL PROTECTIVE EFFECTS OF LOSARTAN

STUDY TO EVALUATE THE RENAL PROTECTIVE EFFECTS OF LOSARTAN
评估氯沙坦肾脏保护作用的研究
批准号：
6297395
负责人：
PATRICK H NACHMAN
金额：
$0.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297395
关键词：
clinical research combination chemotherapy comorbidity creatinine diabetes mellitus therapy diabetic nephropathy hemodialysis human subject human therapy evaluation hypoglycemic agents kidney transplantation losartan noninsulin dependent diabetes mellitus proteinuria

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中文摘要
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英文摘要
The primary objective of this study will be to investigate whether losartan (+ conventional therapy) compared to placebo (+ conventional therapy) will reduce the number of patients with NIDDM and early nepropathy who experience doubling of serum creatinine, ESRD (dialysis or renal transplantation) or death. The secondary objective will compare the effect of losartan to placebo on cardiovascular morbidity and mortality, proteinuria, and safety and tolerability. Teritary parameters include quality of life and health care resource utilization.
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