HYPERIMMUNE EGG YOLKS FOR AIDS RELATED CRYPTOSPORIDIAL DIARRHEA

这是一项评估高免疫蛋黄(IGX-CP)在艾滋病和环孢子虫腹泻患者中的安全性、耐受性和有效性的开放标签先导性研究。进度报告和调查结果摘要：这项研究先前已结束。调查结果的分析正在进行中。24名受试者入选并接受治疗。24例可评价受试者中，16例(56%)排便次数减少，6例(38%)大便卵囊分级降低，而1例(19%)大便卵囊分级增加。没有受试者经历了粪便隐孢子虫卵囊的持续根除。虽然治疗被发现是安全的，但胃肠道症状(饱腹感)限制了IGX-CP的剂量，每天超过2.88×10(6)AU。

This is an open label pilot study to assess the safety, tolerance and efficacy of hyperimmune egg yolks (IGX-CP) in patients with AIDS and cyrptosporidial diarrhea. Progress report and summary of findings: This study had been previously concluded. Analysis of findings is ongoing. Twenty-four subjects were enrolled and treated. 16 of the 24 evaluable subjects (56%) had a reduction in bowel movement frequency, and 6 subjects (38%) had a reduction in stool oocyst grade as compared with 1 subject (19%) in whom stool oocyst grade increased. No subject experienced sustained eradication of stool Cryptosporidium oocysts. While treatment was found to be safe, gastrointestinal symptoms (satiety) limited administration of IGX-CP at doses above 2.88 x10(6) AU/day.