SAFETY & EFFICACY OF CLARITHROMYCIN FOR AIDS-RELATED CRYPTOSPORIDIAL DIARRHEA

安全

• 批准号: 6245109
• 负责人: ROSEMARY SOAVE
• 金额: $ 5.36万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-24 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245109
• 关键词: AIDS therapy; Cryptosporidium; HIV infections; clarithromycin; clinical research; cryptosporidiosis; diarrhea; dosage forms; drug screening /evaluation; gastrointestinal drug absorption; human subject; human therapy evaluation; malabsorption; parasitic disease chemotherapy; pharmacokinetics; xylose

Previous work with macrolides suggests that this class of agents may have activity against this parasite. The aims of this study are to: (1)evaluate the safety and efficacy of ascending doses of clarithromycin (2)compare the absorption and tolerability of the tablet and liquid forms of cla rithromycin; and (3)evaluate the impact of malabsorption, as measured by d-xy-lose absorption, on the bioavailability and efficacy of clarithromycin for AID related cryptosporidial enteritis.

以前对大环内酯类药物的研究表明，这类药物可能具有 对这种寄生虫的作用。 这项研究的目的是： （1）评价克拉霉素递增剂量的安全性和有效性 （2）比较片剂和液体形式的吸收和耐受性 和（3）评价吸收不良的影响， 通过d-木糖吸收测量，对 克拉霉素治疗AID相关隐孢子虫肠炎。