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PLACEBO CONTROLLED SAFETY/EFFICACY STUDY OF AMINOGUANIDINE IN DIABETIC PATIENTS

PLACEBO CONTROLLED SAFETY/EFFICACY STUDY OF AMINOGUANIDINE IN DIABETIC PATIENTS
氨基胍在糖尿病患者中的安慰剂对照安全性/有效性研究
批准号：
6219250
负责人：
TREVOR J. ORCHARD
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219250
关键词：
aminoguanidine clinical research diabetic nephropathy drug adverse effect drug screening /evaluation human subject human therapy evaluation insulin dependent diabetes mellitus kidney disorder chemotherapy kidney function kidney imaging /visualization medical complication radiography urinalysis

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英文摘要
The primary objective of this trial is to evaluate the safety & efficacy of aminoguanidine in preserving renal function in patients with insulin dependent diabetes mellitus & overt diabetic nephropathy. Secondary; 1)to evaluate the effect of aminoguanidine on protein crosslinking in diabetic pts as measured by circulating blood and urinary concentrations of advanced glycated endproducts (AGEs),2) to evaluate the relationship between plasma aminoguanidine concentra-tions and primary and secondary efficacy endpoints as well as adverse events...
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