EFFECTS OF COMPULSIVE EDUCATIONAL BEHAVIOR HTN AFRICAN AMERICAN MEN

强制教育行为 HTN 对非洲裔美国男性的影响

• 批准号: 6114427
• 负责人: WENDY S POST
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114427
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; cardiovascular disorder education; clinical research; echocardiography; electrocardiography; familial hypertension; genetic polymorphism; health behavior; heart dimension /size; human subject; longitudinal human study; male; outcomes research; patient care management; renin; renin angiotensin system; ventricular hypertrophy

The purpose of this supplement to Dr. Martha Hill's YBMII hypertension study, is to evaluate the difference in left ventricular mass (LVM), measured with echocardiography, between the men in the special intervention versus the men in the usual care group. The hypothesis is that the special intervention will lead to a smaller increase in LVM over 2 years of follow-up than the usual care group, or to a reduction in LVM. In addition, we are measuring changes in voltage on ECG, as a secondary measure of LVM regression, and carotid tonometry measurement of augmentation index as a measure of central vascular stiffness. Plasma renin and angiotensin II are measured to define the presence of low renin hypertension in this group of African-American men. The buffy coat is saved for DNA analysis of genetic polymorphisms related to the renin-angiotensin system. We will analyze the association between renin and angiotensin II levels and left ventricular hypertrophy, and also the association between genetic polymorphisms and left ventricular hypertrophy.

此补充剂对 Martha Hill 博士的 YBMII 高血压的目的 研究的目的是评估左心室质量（LVM）的差异， 通过超声心动图测量，在特殊的男性之间 干预与常规护理组中的男性进行比较。 假设 是特殊干预会导致LVM增幅较小 比常规护理组随访超过 2 年，或减少 在LVM中。 此外，我们正在测量心电图上的电压变化，作为 LVM 回归的辅助测量和颈动脉张力测量 增强指数作为中央血管硬度的测量。 测量血浆肾素和血管紧张素 II 以确定是否存在 这组非洲裔美国男性的肾素高血压较低。 巴菲 保存外套用于与相关的遗传多态性进行 DNA 分析 肾素-血管紧张素系统。 我们将分析肾素之间的关联 和血管紧张素 II 水平和左心室肥厚，以及 基因多态性与左心室的关系 肥大。