EPILEPSY AS NEUROLOGICAL MODEL OF SCHIZOPHRENIA

癫痫作为精神分裂症的神经学模型

• 批准号: 6264067
• 负责人: LAURA MARSH
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264067
• 关键词: brain mapping; clinical research; clinical trial phase I; comorbidity; disease /disorder model; epilepsy; human subject; neuropathology; pathologic process; schizophrenia

The broad objectives of this proposal are to identify converging clinical, neuroanatomical, and electrophysiological features and clinicopathological relationships in idiopathic schizophrenia (ISZ) as compared to epilepsy patients with interictal schizophrenia-like syndromes (ESZ) and localization-related epilepsy of unilateral temporal lobe or frontal lobe origin without interictal psychosis. Healthy controls provide normative EEG, MRI, and neuropsychological data. Such knowledge will help establish the location, specificity, and pathophysiological significance of abnormalities in ISZ and further direct studies of regional neuropathology and brain dysfunction in ISZ to focus on areas of etiologic significance. Findings to date show that the ESZ subjects resemble the ISZ subjects clinically, with prominent psychotic as well as negative symptoms, as well as similar evidence for prefrontal cognitive dysfunction. As such, ESZ represents a clinical phenotype of idiopathic schizophrenia. The neuroanatomical data to date show evidence for temporal lobe and extratemporal lobe cortical gray matter deficits in the ISZ, ESZ, and nonpsychotic TLE subjects. However, the deficits are significantly greater in the ESZ. This suggests commonalties in the underlying pathology of epilepsy and schizophrenia, with an enhancement of cortical gray matter abnormalities when both conditions co-occur.

本研究的主要目的是确定特发性精神分裂症(ISZ)的临床、神经解剖学和电生理特征以及临床病理关系，并与发作期精神分裂样综合征(ESZ)的癫痫患者和无发作间期精神病的单侧颞叶或额叶起源的定位相关癫痫患者进行比较。健康对照组提供标准的EEG、MRI和神经心理学数据。这些知识将有助于确定ISZ异常的位置、特异性和病理生理学意义，并进一步指导ISZ的局部神经病理学和脑功能障碍的研究，以专注于病因学意义的区域。到目前为止的研究结果表明，ESZ受试者在临床上与ISZ受试者相似，具有突出的精神病症状和阴性症状，以及类似的前额叶认知功能障碍的证据。因此，ESZ代表了特发性精神分裂症的一种临床表型。迄今为止的神经解剖学数据显示，在ISZ、ESZ和非精神病性TLE受试者中，存在颞叶和颞叶外皮质灰质缺陷的证据。然而，ESZ的赤字要大得多。这表明癫痫和精神分裂症的基本病理有共同之处，当这两种情况同时发生时，皮质灰质异常增强。