POSTMENOPAUSAL HRT AFTER CORONARY BYPASS SURGERY (EAGAR)

冠状动脉绕道手术 (EAGAR) 后的绝经后 HRT

• 批准号: 6122764
• 负责人: DAVID McLeod HERRINGTON
• 金额: $ 3.88万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122764
• 关键词: cardiovascular disorder prevention; chemoprevention; clinical research; coronary bypass; estrogens; female; hormone therapy; human morbidity; human subject; human therapy evaluation; postmenopause; postoperative state; progestins

Coronary atherosclerosis is the major cause of death in women in the USA. Coronary artery bypass surgery decreases symptomatic and clinical evidence in cardiac ischemia but does not alter the underlying process. Patients may develop recurrent symptoms. Observational studies suggest that postmenopausal estrogen replacement therapy reduces cardiac morbidity by 50%. This study aims to establish the benefit of estrogen and progestin co- therapy in women with coronary disease.

冠状动脉粥样硬化是美国女性死亡的主要原因。 冠状动脉搭桥手术减少症状和临床证据 但不会改变潜在的过程。 患者 可能会出现复发症状。观察性研究表明， 绝经后雌激素替代疗法通过以下途径降低心脏病发病率： 百分之五十本研究的目的是建立雌激素和孕激素共同作用的益处， 患有冠状动脉疾病的女性的治疗。