DHEA CAN ENHANCE SUCCESS OF SMOKING CESSATION PROGRAM

DHEA 可以提高戒烟计划的成功率

• 批准号: 6298343
• 负责人: FRANK SVEC
• 金额: $ 1.97万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298343
• 关键词: blood chemistry; clinical research; clinical trial phase I; dehydroepiandrosterone; female; hormone therapy; human subject; human therapy evaluation; pharmacokinetics; smoking cessation

The purpose of this study is to determine whether the hormone DHEA (dehydroepiandrosterone: a natural hormone produced in the adrenal glands of humans) makes it easier to stop smoking. Women who smoke have higher levels of DHEA in their serum. When they stop smoking, this level drops. There is some evidence that falling DHEA levels may cause problems. It is possible that by giving a person DHEA, it will be easier to stop smoking. This study is designed to evaluate how much DHEA a woman who does not smoke needs to take in order to attain the same level of DHEA in the blood of a woman who smokes. This will allow assessment of how much DHEA needs to be given to a person while they stop smoking in order to keep their serum DHEA level at the same level as while they were smoking.

本研究的目的是确定激素 DHEA 是否 （脱氢表雄酮：肾上腺产生的天然激素 人类）使戒烟更容易。吸烟的女性患病率更高 他们血清中的 DHEA 水平。当他们停止吸烟时，这一水平就会下降。 有一些证据表明 DHEA 水平下降可能会导致问题。它 是否有可能通过给予一个人 DHEA，会更容易戒掉 吸烟。本研究旨在评估女性体内的 DHEA 含量 不吸烟需要服用才能达到相同水平的 DHEA 存在于吸烟女性的血液中。这将允许评估如何 为了戒烟，需要给一个人大量的 DHEA 使他们的血清 DHEA 水平保持在与治疗时相同的水平 吸烟。