EFFECT OF MEALS ON SERUM DHEA

膳食对血清 DHEA 的影响

• 批准号: 6122092
• 负责人: FRANK SVEC
• 金额: $ 1.12万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-19 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122092
• 关键词: clearance rate; clinical research; clinical trials; dehydroepiandrosterone; eating; hormone biosynthesis; hormone regulation /control mechanism; human subject; insulin; nutrient interaction; nutrition related tag

DHEA is a hormone made in the adrenal gland that appears to protect people from heart attacks. At this time little is known about those factors that control the level of this hormone in the blood. One condition that stimulates the adrenal gland is the consumption of a meal. Hence, it was anticipated that when a person ate, his blood level of DHEA should rise. However, the Principal Investigator found in preliminary studies, that the level actually goes down with meals. Others have shown that insulin enhances the clearance (or removal) of DHEA from the serum. It is often reasoned that the decrease in serum DHEA is caused by the rise in insulin of a meal. The goal of this project is to test this hypothesis by monitoring the fall of DHEA and comparing it with the increase in insulin in response to a standard meal.

脱氢表雄酮是一种肾上腺分泌的激素，似乎可以保护人们免受心脏病发作。 在这个时候，很少有人知道这些因素控制这种激素在血液中的水平。 刺激肾上腺的一个条件是吃饭。 因此，当一个人吃东西时，他的血液DHEA水平应该会上升。然而，首席研究员在初步研究中发现，该水平实际上随着膳食而下降。 其他研究表明，胰岛素可增强DHEA从血清中的清除（或去除）。 通常认为，血清DHEA的减少是由膳食中胰岛素的升高引起的。 该项目的目标是通过监测DHEA的下降并将其与标准膳食中胰岛素的增加进行比较来验证这一假设。