CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI

CLIN CTR WHI 临床试验/观察研究

• 批准号: 6354564
• 负责人: ROWAN T. CHLEBOWSKI
• 金额: --
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2005-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6354564
• 关键词: breast neoplasms; calcium; clinical research; clinical trials; colorectal neoplasms; coronary disorder; diet; disease /disorder prevention /control; disease /disorder proneness /risk; estrogens; female; hip fractures; hormone therapy; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; longitudinal human study; nutrition related tag; osteoporosis; postmenopause; quality of life; questionnaires; stroke; therapy compliance; vitamin D; women's health

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

妇女健康倡议是一项随机对照临床研究