EFFECT OF ANDROGEN REPLACEMENT ON FAT METABOLISM

衰老与身体脂肪增加有关，特别是在 后备箱。这种体脂和体脂分布的变化与 胰岛素抵抗、高血压、血脂异常和糖尿病。 老年男性循环雄激素水平降低与 胰岛素抵抗和体内脂肪集中，而水平降低 脱氢表雄酮与上半身脂肪分布有关 男人和女人。如果降低水平的生理性替代 睾丸素(男性)或脱氢表雄酮(男性和女性)可以逆转一些衰老 体脂分布和脂肪酸代谢的相关变化，这 可以提供一种改善健康的手段，因为美国人口 继续变老。目前的实验将评估逆转 与年龄相关的雄激素和脱氢表雄酮的下降可以对 老年人体脂分布和脂肪酸代谢的研究至 为了实现这些目标，拟议的实验将解决 具体目标如下：1)确定体脂变化是否 实验将解决以下具体目标：1)确定 体脂实验中的变化是否会解决以下问题 具体目标：1)确定体内脂肪的变化 随着年龄增长而出现的分布与年龄的差异有关 全身性FFA利用率、脂肪酸氧化和局部脂肪 组织餐脂肪酸摄取；2)测定脂肪是否发生变化 睾酮替代疗法预计会出现的分布是 随着FFA新陈代谢的改善，脂肪酸增加 氧化，或脂肪组织膳食脂肪酸摄取的变化；3) 确定脱氢表雄酮替代疗法在老年人中是否相关 减少身体脂肪和上半身脂肪，如果是这样的话，评估DHEA 对游离脂肪酸代谢、脂肪酸氧化和局部脂肪的影响 组织餐脂肪酸摄取。为了解决这些具体目标，我们 将使用最先进的身体成分技术，测量脂肪 餐后FFA释放、静息时脂肪酸氧化的评估 消耗，以及在锻炼期间。此外，我们还将应用相对 测定区域性脂肪组织膳食脂肪酸的新技术 吸收父亲关于脂肪潜在机制的信息 重新分配。

Aging is associated with increased body fatness, particularly in the trunk. This change in body fat and body fat distribution correlates with insulin resistance, hypertension, dyslipidemia and diabetes mellitus. Reduced levels of circulating androgens in aging men are associated with insulin resistance and centralization of body fat, whereas reduced levels of DHEA are associated with an upper body fat distribution in both aging men and women. If physiologic replacement of reduced levels of testosterone (men) or DHEA (men and women) can reverse some of the aging related changes in body fat distribution and fatty acid metabolism, this could provide a means of improving health as the United States population continues to age. The present experiments will assess whether reversing the age-related decline in androgens and DHEA can have positive effects on body fat distribution and fatty acid metabolism in the elderly. To accomplish these goals, the proposed experiments will address the following specific aims: 1) to determine whether the changes in body fat experiments will address the following specific aims: 1) to determine whether the changes in body fat experiments will address the following specific aims: 1) to determine whether the changes in body fat distribution which occur with aging are associated with differences in systemic FFA availability, fatty acid oxidation, and regional adipose tissue meal fatty acid uptake; 2) to determine whether the change in fat distribution expected to occur with testosterone replacement therapy is associated with improvements in FFA metabolism, increased fatty acid oxidation, or changes in adipose tissue meal fatty acid uptake; 3) to determine whether DHEA replacement therapy in the elderly is associated with decreased body fat and upper-body fat and, if so, to assess DHEA's effects on FFA metabolism, fatty acid oxidation and regional adipose tissue meal fatty acid uptake. In order to address these specific aims we will use state-of-the-art body composition techniques, measures of adipose FFA release, assessments of fatty acid oxidation at rest, following meal consumption, and during exercise. In addition, we will apply a relatively new technique of determining regional adipose tissue meal fatty acid uptake to father information about potential mechanisms of fat redistribution.