DESIGN OF NEW NUCLEOSIDES BASED ON ENZYME SPECIFICITIES
基于酶特异性的新核苷设计
基本信息
- 批准号:6300244
- 负责人:
- 金额:$ 30.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-02-01 至 2001-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The long-term goal of this project remains the development of new agents
for the treatment of human cancers. Since most, if not all, of the
nucleosides currently in use for the treatment of human cancers must
phosphorylated to their active forms, we plan to investigate in some detail
the enzymes that are known to carry out this activation. Deoxycytidine
kinase is the primary, but not the only, enzyme that initiates this
activation process, so we plan to focus on it, in collaboration with Dr.
Donna S. Shewach of the University of michigan. We plan to prepare a broad
series of compounds with a focus on them activating enzymes as well as
their antitumor selectivity.
We also plan to examine our collection of nucleoside triphosphates as
inhibitors of telomerase, a DNA polymerase which is activated in human
cancers. The studies will show triphosphates we have on hand or easily
generate, and will provide us with SAR information that will be used in
designing new compounds that will be more specific inhibitors for this
enzyme, which appears to be an important new target for can chemotherapy.
该项目的长期目标仍然是开发新的代理商
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JOHN A SECRIST', 18)}}的其他基金
4'-Substituted nucleoside analogs as anticancer drugs
4-取代核苷类似物作为抗癌药物
- 批准号:
8212510 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
Drug Design and Synthesis for Orthopoxvirus Infections
正痘病毒感染的药物设计与合成
- 批准号:
7652108 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
4'-Substituted nucleoside analogs as anticancer drugs
4-取代核苷类似物作为抗癌药物
- 批准号:
7464122 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
4'-Substituted nucleoside analogs as anticancer drugs
4-取代核苷类似物作为抗癌药物
- 批准号:
8018541 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
4'-Substituted nucleoside analogs as anticancer drugs
4-取代核苷类似物作为抗癌药物
- 批准号:
7758375 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
4'-Substituted nucleoside analogs as anticancer drugs
4-取代核苷类似物作为抗癌药物
- 批准号:
7585807 - 财政年份:2008
- 资助金额:
$ 30.5万 - 项目类别:
DESIGN OF NEW NUCLEOSIDES BASED ON ENZYME SPECIFICITIES
基于酶特异性的新核苷设计
- 批准号:
6563806 - 财政年份:2002
- 资助金额:
$ 30.5万 - 项目类别:
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