CORE--AUTISM SUBJECTS

主题核心的目标是： 1)招募200名经过严格诊断的高功能自闭症患者 在5年的研究期间， 2)招募200名个体匹配的正常对照， 发育和神经精神病的个人和家族史 疾病，加上10个额外的平均智商正常对照， 纵向研究， 3)根据最有可能的临床表现来描述自闭症患者 四个独立的遗传亚组（家族史）的指标 自闭症的“较小变异”，情绪障碍或焦虑的家族史 障碍，作为自闭症发作模式的回归，以及外周血淋巴细胞 血清素水平）， 4)进行神经心理学和认知心理学测试 项目一和项目二，以及 5)为所有受试者提供行为管理和支持， 项目II和III中的fMRI和实验室眼动程序。

The objectives of the Subject core are to: 1) recruit 200 rigorously diagnosed high functioning autistic subjects over the 5 year period of study, 2) recruit 200 individually matched normal controls who have a negative personal and family history of developmental and neuropsychiatric disorders, plus 10 additional normal controls of average IQ for the longitudinal study, 3) characterize autistic subjects in terms of the most likely clinical indicators of four separate genetic subgroups (family history of "lesser variant" of autism, family history of mood disorder or anxiety disorder, regression as mode of autism onset, and elevated peripheral serotonin levels), 4) administer the neuropsychologic and cognitive psychology testing from Projects I and II, and 5) provide behavioral management and support for all subjects during fMRI and laboratory eye movement procedures in Projects II and III.