CORE--AUTISM SUBJECTS

学科核心的目标是： 1)招募200名经过严格诊断的高功能自闭症患者 在五年的学习期间， 2)招募200名阴性的单独匹配的正常对照组 发育和神经精神病学的个人和家族病史 精神障碍，外加10名正常儿童的平均智商 纵向研究， 3)根据最有可能的临床特征来描述自闭症患者 四个不同遗传亚组的指标(家族史 自闭症、有情绪障碍或焦虑症家族史的“次要变种” 精神障碍、自闭症发病方式倒退和外周血缘升高 5羟色胺水平)， 4)实施神经心理学和认知心理学测验 来自项目I和项目II，以及 5)为所有受试者提供行为管理和支持 项目二和项目三中的功能磁共振成像和实验室眼球运动程序。

The objectives of the Subject core are to: 1) recruit 200 rigorously diagnosed high functioning autistic subjects over the 5 year period of study, 2) recruit 200 individually matched normal controls who have a negative personal and family history of developmental and neuropsychiatric disorders, plus 10 additional normal controls of average IQ for the longitudinal study, 3) characterize autistic subjects in terms of the most likely clinical indicators of four separate genetic subgroups (family history of "lesser variant" of autism, family history of mood disorder or anxiety disorder, regression as mode of autism onset, and elevated peripheral serotonin levels), 4) administer the neuropsychologic and cognitive psychology testing from Projects I and II, and 5) provide behavioral management and support for all subjects during fMRI and laboratory eye movement procedures in Projects II and III.