PLATELET DERIVED GROWTH FACTOR (PDGF) IN VESSEL DEVELOPMENT AND PATHOLOGY

血管发育和病理学中的血小板衍生生长因子 (PDGF)

• 批准号: 6302084
• 负责人: DANIEL F BOWEN-POPE
• 金额: $ 17.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302084
• 关键词: angiogenesis; atherosclerotic plaque; cell growth regulation; cell migration; fusion gene; genetically modified animals; growth factor receptors; laboratory mouse; laboratory rat; platelet derived growth factor; tissue mosaicism; vascular endothelium

Platelet-derived growth factor (PDGF) has been hypothesized to play important roles in driving migration and proliferation of vascular cells during development and in vascular diseases. Attempts to test these hypotheses in vivo have produced results which are incomplete or inconsistent. This motivated us to develop experimental approaches which allow us to directly compare the behavior, in vivo, of cells which can, or cannot, express components of the PDGF/PDGF receptor system. These approaches allow us to determine the roles of the individual cells. At the same time, the approach provides information about the processes of cell migration and clonal expansion that contribute to the assembly of vessels during development, and that may later be involved in vascular changes in vascular diseases. These include processes which contribute to the apparent monoclonality of atherosclerotic lesions and the possible contribution of circulating precursors to the endothelium of vessels during tissue remodeling.

血小板衍生生长因子(PDGF)已被假想起作用 在推动血管细胞迁移和增殖中的重要作用 在发育过程中和血管疾病中。尝试测试这些 体内的假设产生了不完整或不完整的结果 前后不一致。这促使我们开发了实验方法， 使我们能够直接比较细胞在体内的行为，这些细胞可以 不能表达PDGF/PDGF受体系统的组成部分。这些 方法使我们能够确定单个细胞的角色。在 同时，该方法提供了关于细胞过程的信息 有助于血管组装的迁移和克隆扩张 在发育过程中，这可能在以后参与血管的变化 血管疾病。这些进程包括对 动脉粥样硬化病变的表观单克隆性及其可能的 循环前体对血管内皮细胞的贡献 在组织重塑过程中。