PLATELET DERIVED GROWTH FACTOR (PDGF) IN VESSEL DEVELOPMENT AND PATHOLOGY

血小板源性生长因子（PDGF）被假设为 在驱动血管细胞迁移和增殖中的重要作用 在发育和血管疾病中。尝试测试这些 体内假设产生的结果是不完整的， 前后矛盾这促使我们开发实验方法， 使我们能够直接比较体内细胞的行为， 不能表达PDGF/PDGF受体系统的组分。这些 这些方法使我们能够确定单个细胞的作用。在 同时，该方法还提供了有关细胞过程的信息， 有助于血管组装的迁移和克隆扩张 在发育过程中，这可能涉及到血管的变化， 血管疾病其中包括有助于 动脉粥样硬化病变的明显单克隆性和可能的 循环前体对血管内皮的贡献 在组织重塑过程中。

Platelet-derived growth factor (PDGF) has been hypothesized to play important roles in driving migration and proliferation of vascular cells during development and in vascular diseases. Attempts to test these hypotheses in vivo have produced results which are incomplete or inconsistent. This motivated us to develop experimental approaches which allow us to directly compare the behavior, in vivo, of cells which can, or cannot, express components of the PDGF/PDGF receptor system. These approaches allow us to determine the roles of the individual cells. At the same time, the approach provides information about the processes of cell migration and clonal expansion that contribute to the assembly of vessels during development, and that may later be involved in vascular changes in vascular diseases. These include processes which contribute to the apparent monoclonality of atherosclerotic lesions and the possible contribution of circulating precursors to the endothelium of vessels during tissue remodeling.