WOMENS ANGIOGRAPHIC VITAMIN & ESTROGEN (WAVE) TRIAL

女性血管造影维生素

• 批准号: 6302995
• 负责人: WILLIAM J ROGERS
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302995
• 关键词: angiography; ascorbate; cardiovascular disorder chemotherapy; cardiovascular disorder prevention; clinical research; clinical trials; coronary artery; estrogens; female; hormone therapy; human subject; human therapy evaluation; postmenopause; tocopherols; vitamin therapy

The purpose of WAVE is to determine if female hormone replacement therapy (HRT) or antioxidant vitamins (c and E) will limit the progression of coronary artery disease (CAD) in post-menopausal women. This NHLBI-multicenter trial has randomized post-menopausal women with angiographicall documented CAD to HRT, vitamins, both or neither. After approximately 3 years follow-up, the subjects will undergo repeat coronary arteriography. The baseline and follow-up arteriograms will be compared to assess if the therapies were beneficial.

WAVE的目的是确定女性激素替代疗法(HRT)或抗氧化维生素(C和E)是否会限制绝经后女性冠状动脉疾病(CAD)的进展。这项NHLBI多中心试验随机选择了接受血管造影术的绝经后妇女，所有人都有冠心病到激素替代疗法、维生素、两者都有或两者都没有的记录。经过大约3年的随访，受试者将再次接受冠状动脉造影术。将比较基线动脉造影和后续动脉造影，以评估治疗是否有效。