WOMENS ISCHEMIC SYNDROME EVALUATION

女性缺血综合症评估

• 批准号: 6565403
• 负责人: WILLIAM J ROGERS
• 金额: $ 17.53万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6565403
• 关键词: clinical research; diagnosis design /evaluation; female; heart disorder diagnosis; human subject; method development; myocardial ischemia /hypoxia; women's health

This multicenter NHLBI-sponsored inveestigation is seeking more accurate methods for diagnosing myocardial ischemia in women. It is recognized that all of the available modalities for assessing ischemia (history, ECG, exercise treadmill, echo and nuclear imaging) are less reliable in women than men. Women's Ischemic Syndrome Evaluation (WISE) is examining innovative technology for assessing ischemia at four medical centers - University of Alabama at Birmingham, University of Florida, University of Pittsburgh and Allegheny General Hospital. At UAB the innovative technology consists of magnetic resonance imaging of the heart both at rest and following intravenous persantine. All patients undergo coronary arteriography for usual clinical indications and also intravenous persantine. All patients undergo coronary arteriography for usual clinical indications and also receive a conventional radionuclide perfusion imaging study. Other centers are evaluating MRI coronary arteriography, positron emission tomography (PET), intracoronary vasoactive infuions, and dobutamine echo.

这项由NHLBI发起的多中心调查正在寻求更准确的 诊断妇女心肌缺血的方法。 应认识 所有用于评估局部缺血的可用模式（病史，ECG， 运动平板、超声心动图和核成像）在女性中的可靠性较低 而不是男人。 妇女缺血综合征评估（WISE）正在检查 在四个医疗中心评估缺血的创新技术- 亚拉巴马大学伯明翰分校、佛罗里达大学、 匹兹堡和阿勒格尼综合医院在UAB， 技术包括心脏的磁共振成像， 休息后静脉注射潘生丁。所有患者均接受冠状动脉造影 动脉造影用于常见的临床适应症，也可用于静脉内 潘生丁所有患者均接受冠状动脉造影检查， 并且还接收常规放射性核素灌注成像 study. 其他中心正在评估磁共振冠状动脉造影，正电子 放射断层扫描（PET）、冠状动脉内血管活性物质输注，以及 多巴酚丁胺回波