WOMENS ISCHEMIC SYNDROME EVALUATION

女性缺血综合症评估

• 批准号: 6303023
• 负责人: WILLIAM J ROGERS
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303023
• 关键词: clinical research; diagnosis design /evaluation; female; heart disorder diagnosis; human subject; method development; myocardial ischemia /hypoxia; women's health

WISE is an NHLBI-sponsored study to seek improved methods for identifying myocardial ischemia in women. Four clinical sites are using different technologies. At UAB, WISE testing consists of a combined persantine sestamibi radionuclide perfusion study and a gadolinium MRI perfusion study. All women have undergone diagnostic coronary arteriography for clinically-indicated reasons. Women with minimal or no significant epicardial coronary artery disease undergo P-31 metabolic assessment for microvascular ischemia. Other measurements include assessment of lipids, female hormones, Holter monitoring for ischemia, and long-term follow-up by telephone for clinical events.

WISE是一项由NHLBI赞助的研究，旨在寻求识别女性心肌缺血的改进方法。 四个临床研究中心正在使用不同的技术。 在UAB，WISE测试包括潘生丁-司他米比放射性核素灌注研究和钆MRI灌注研究。 所有女性均因临床原因接受了诊断性冠状动脉造影。 患有轻微或无明显心外膜冠状动脉疾病的女性接受微血管缺血的P-31代谢评估。 其他测量包括评估血脂、女性激素、霍尔特监测缺血和通过电话对临床事件进行长期随访。