EFFECTS OF RACE/ETHNICITY ON ADIPONECTIN LEVELS AND INSULIN ACTION

种族/民族对脂联素水平和胰岛素作用的影响

• 批准号: 7718657
• 负责人: KWAME none OSEI
• 金额: $ 0.21万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718657
• 关键词: Abdomen; African American; American; Attention; Beta Cell; Blood specimen; Body Composition; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; DEXA; Energy Metabolism; Ethnic Origin; Functional disorder; Funding; Future; Glucose; Grant; Hypertension; Indirect Calorimetry; Institution; Insulin; Insulin Resistance; Isotopes; Measurement; Mediating; Metabolic; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathogenesis; Play; Prevention; Race; Recruitment Activity; Research; Research Personnel; Resources; Rest; Role; Scanning; Source; United States National Institutes of Health; Visceral; adiponectin; base; blood glucose regulation; cardiovascular risk factor; caucasian American; impaired glucose tolerance; insulin sensitivity; novel strategies; oxidation; racial difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes (T2DM) and its long-term complications are more prevalent in African Americans than in White Americans (1,2). The pathogenesis of the racial differences in glucose/insulin metabolism and insulin sensitivity remains uncertain. Despite the enormous progress and advancements in understanding the pathogenetic basis of impaired glucose tolerance (IGT) and T2DM, the mechanisms for beta cell dysfunction and insulin resistance that are pivotal for T2DM remain uncertain. There is increasing evidence to indicate that proinflammatory adipocytokines could mediate some of the metabolic derangements leading to T2DM and cardiovascular diseases (CVD) (3-28). Among them, Adiponectin has received greater attention. Adiponectin has been shown to predict future type 2 diabetes, hypertension and coronary artery disease (3-5, 10). The present project will explore the differential role of adiponectin in glucose homeostasis, insulin action and metabolism and substrate oxidation in healthy African Americans (AA) and White Americans (WA). The study will also identify whether the circulating trimers, heterotrimers, hexatrimers etc. are different in African Americans and White Americans. Healthy AA and WA will be recruited to participate in the study. Information collected will include related blood samples, anthropometric measurements, DEXA scan for body composition, abdominal CT to evaluate visceral adiposity, euglycemic-isotope clamp to assess insulin sensitivity and indirect calorimetry to assess resting energy expenditure. It is hopeful that this project will help show how ethnicity plays a role in glucose/insulin metabolism and insulin sensitivity and how adiponectin relates to theses factors. It is hopeful that the stimulation of endogenous adiponectin levels could provide a novel approach for the future prevention and management of type 2 diabetes and perhaps cardiovascular risk factors in African Americans.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 2型糖尿病（T2 DM）及其长期并发症在非裔美国人中比在白色美国人中更普遍（1，2）。 葡萄糖/胰岛素代谢和胰岛素敏感性的种族差异的发病机制仍然不确定。 尽管在了解糖耐量受损（IGT）和T2 DM的发病机制方面取得了巨大进展，但对T2 DM至关重要的β细胞功能障碍和胰岛素抵抗的机制仍不确定。 越来越多的证据表明，促炎性脂肪细胞因子可介导导致T2 DM和心血管疾病（CVD）的某些代谢紊乱（3-28）。 其中，脂联素受到了较大的关注。脂联素已被证明可以预测未来的2型糖尿病，高血压和冠状动脉疾病（3-5，10）。 本项目将探讨脂联素在健康的非裔美国人（AA）和白色美国人（WA）的葡萄糖稳态、胰岛素作用和代谢以及底物氧化中的不同作用。本研究还将确定非裔美国人和白色美国人的循环三聚体、异源三聚体、六聚体等是否不同。 将招募健康AA和WA参与研究。 收集的信息将包括相关的血液样本、人体测量、身体成分的DEXA扫描、评估内脏肥胖的腹部CT、评估胰岛素敏感性的正常血糖同位素钳夹和评估静息能量消耗的间接热量测定。 希望本研究能有助于揭示种族在葡萄糖/胰岛素代谢和胰岛素敏感性中的作用，以及脂联素与这些因素的关系。 这是有希望的内源性脂联素水平的刺激可以提供一种新的方法，为未来的预防和管理2型糖尿病，也许心血管危险因素在非洲裔美国人。