CORONARY ARTERY DISEASE RISKS IN AMERICAN & KOREAN POST RENAL TRANSPLANTATION

美国人的冠状动脉疾病风险

• 批准号: 6304517
• 负责人: HAEWOK HAN
• 金额: $ 4.28万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304517
• 关键词: Asian Americans; body weight; caucasian American; clinical research; comorbidity; coronary disorder; cyclosporines; diabetes mellitus; diet; epidemiology; gene environment interaction; genetic susceptibility; homocysteine; human data; hyperlipidemia; kidney transplantation; nutrition related tag; postoperative state; prednisone; racial /ethnic difference; steroid metabolism disorder

Coronary artery disease (CAD) is the leading cause of death (46%) among post-renal transplant patients in the United States. CAD risks among post-renal transplant patients are higher than in the general population because these patients have pre-existing medical problems such as diabetes and hypertension, physical inactivity and are taking drugs which may further increase risks. Korean post-renal patients may have lower CAD risks than Americans because of their different dietary intakes which are very low in fat, saturated fat, cholesterol, calories, and simple sugars. Also, other nutritional status measures such as body weight may decrease risks of CAD among Korean post-renal transplant patients. However other factors such as high homocysteine levels or weight gain after transplant may increase risk among them. A comparison of both genetic or environmental CAD risk factors among Korean and American post-renal transplant patients will provide useful comparative information. The study will also help in crafting nutritional interventions among post-renal transplant patients especially in Korea, where little has been done until now.

冠状动脉疾病(CAD)是美国肾移植后患者的主要死亡原因(46%)。肾移植术后患者的冠心病风险高于普通人群，因为这些患者既有糖尿病和高血压等疾病，又有运动不足，并且正在服用可能会进一步增加风险的药物。韩国肾病后患者的冠心病风险可能比美国人低，因为他们的饮食摄入量不同，脂肪、饱和脂肪、胆固醇、卡路里和单糖的摄入量都非常低。此外，体重等其他营养状况指标可能会降低韩国肾移植后患者患冠心病的风险。然而，其他因素，如同型半胱氨酸水平高或移植后体重增加，可能会增加他们之间的风险。对韩国和美国肾移植后患者的遗传或环境CAD危险因素进行比较将提供有用的比较信息。这项研究还将有助于在肾移植后患者中制定营养干预措施，特别是在韩国，因为到目前为止，韩国几乎没有采取任何措施。