9 高级非小细胞肺 CA 中的 AC 胶体分散输注-猫眼课题宝

9 高级非小细胞肺 CA 中的 AC 胶体分散输注

批准号：

6305353

负责人：

NATHAN LEVITAN

金额：

$1.92万

依托单位：

CASE WESTERN RESERVE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-12-01 至 2000-11-30

来源：

https://reporter.nih.gov/project-details/6305353

关键词：

DNA topoisomerases antineoplastics clinical research drug screening /evaluation human subject human therapy evaluation intravenous administration neoplasm /cancer chemotherapy pharmacokinetics small cell lung cancer

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英文摘要

The objectives of this trial are to: To determine if 9-aminocamptothecin CD administered as a 120h weekly infusion is an effective agent of treatment of advanced non-small cell lung cancer. To observe the toxicity associated with this regimen among patients with advanced nonsmall cell lung cancer. To measure the levels of topoisomerase I in tumor biopsy specimens obtained from patients with non small cell lung cancer entered on this trial. To determine the 9-AC pharmacokinetics parameters and to correlate serum levels with toxicity and response to treatment. To determine the mutagenic potential of 9-AC administered as a 120hr weekly infusion."

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