Drug resistance in DNA repair defective ovarian cancer

卵巢癌是妇女癌症死亡的主要原因，因为目前的治疗方法不足。一半的侵袭性卵巢癌在DNA修复中有异常，对新的PARP抑制剂治疗有反应，但即使这样，癌症也经常复发。我将用一种新的模型在老鼠身上研究人类卵巢癌。我的重点将是了解个体卵巢癌对PARP抑制剂的耐药性，并设计克服这种耐药性的方法。

Ovarian cancer is a major cause of cancer death in women because current treatments are inadequate. Half of aggressive ovarian cancers have abnormalities in DNA repair and respond to new PARP inhibitor therapy, yet even then the cancer often recurs. I will use a new model to study human ovarian cancers in mice. My focus will be understanding resistance to PARP inhibitors in individual ovarian cancers and designing approaches to overcome this resistance.