EFFECTS OF PHYSIOLOGICAL DOSES OF MELATONIN ON HUMAN SLEEP BEHAVIOR

褪黑激素生理剂量对人类睡眠行为的影响

• 批准号: 6305692
• 负责人: RICHARD J WURTMAN
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305692
• 关键词: attention; blood chemistry; circadian rhythms; clinical research; dosage; electroencephalography; hormone metabolism; hormone regulation /control mechanism; human subject; melatonin; neurophysiology; psychomotor function; sleep

Examines the acute behavioral, EEG and hormonal changes that occur when humans exposed to the physiological doses of the hormone at noon, early evening and late evening. This will test the relationship between the efficacy of melatonin doses and circadian time. Levels of alertness and psychomotor performance will be continuously assessed. EEG patterns during 2 hour sleep test will be registered and blood samples will be taken via indwelling venous catheter for determination of serum melatonin levels.

检查急性行为，脑电图和激素的变化，发生时，人类暴露于生理剂量的激素在中午，傍晚和傍晚。 这将测试褪黑激素剂量的功效与昼夜节律时间之间的关系。将持续评估警觉性和心理表现水平。 记录2小时睡眠试验期间的EEG模式，并通过留置静脉导管采集血样，以测定血清褪黑激素水平。