AGING AND SLEEP--ROLE OF MELATONIN

描述(改编自《调查者摘要》)：年龄与 伴随着睡眠和昼夜节律的紊乱。夜间活动 老年人体内的褪黑素水平通常大大低于老年人。 年轻人。研究表明，高药理剂量的 褪黑素产生嗜睡，减少睡眠潜伏期。建议数 研究将检验这一假设，即老年人的睡眠障碍 可能与夜间褪黑激素分泌不足有关，以及 循环中有节奏、高幅度变化的恢复 褪黑素可改善老年人睡眠质量和睡眠质量 第二天早上情绪或表现下降。老年人(60-75岁 年)有无症状的男性和女性参与者(N=60) 经多道描记证实的失眠症将在四岁以下进行测试 条件(安慰剂、0.1、0.2、0.3毫克褪黑素)。睡眠质量和 数量将通过测绘仪进行评估，同时测量 警觉、困倦、情绪和表现。并行的措施 将测量皮质醇和体温。

DESCRIPTION (Adapted from Investigator's Abstract): Aging is associated with disturbances of both sleep and circadian rhythms. Nocturnal melatonin levels in the elderly are often substantially lower than in younger people. Studies have shown that high pharmacological doses of melatonin produce sleepiness and reduce sleep latency. The proposed studies will test the hypothesis that sleep disturbances of the elderly can be related to deficiencies in nocturnal melatonin secretion, and that restoration of rhythmic, high amplitude variations in circulating melatonin can improve sleep quality and quantity in the elderly without diminishing mood or performance the following morning. Elderly (60 -75 years) men and women participants (N=60) with and without symptomatic and polygraphically-confirmed insomnia will be tested under four conditions (placebo, 0.1, 0.2, 0.3 mg melatonin). Sleep quality and quantity will be polygraphically assessed along with measures of alertness, sleepiness, mood and performance. Parallel measures of cortisol and body temperature will be taken.