EFFECT OF 5 LIPOXYGENASE INHIBITOR ON NASAL POLYPOSIS

5脂氧合酶抑制剂对鼻息肉病的影响

• 批准号: 6306952
• 负责人: DAVID A KHAN
• 金额: $ 3.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6306952
• 关键词: clinical research; eosinophil; human subject; human therapy evaluation; hydroxyurea; lipoxygenase; nasopharyngeal neoplasms; nonsteroidal antiinflammatory agent; oxidoreductase inhibitor

The pathophysiology of nasal polyp disease is complex and the etiology is elusive. Nasal polyps often coexist with asthma, allergic rhinitis and aspirin intolerance. An inflammatory infiltrate primarily composed of eosinophils is characteristic of the majority of nasal polyps regardless of the cause. Standard treatment with topical nasal steroids, systemic corticosteroids and surgical removal ofter fails. Zileuton has been shown to be a potent and selective inhibitor of 5-lipoxygenase activity. Improvement in nasal symptoms and polyp size in patients treated with zileuton has been anectdotally observed. The purpose of this study is to compare the efficacy of zileuton and placebo in nasal polyp disease.

鼻息肉病的病理生理复杂，病因不明。 鼻息肉通常与哮喘、过敏性鼻炎和阿司匹林不耐受共存。 鼻息肉的主要病理特征是鼻息肉的大小、形状、大小、 局部鼻用类固醇、全身性皮质类固醇和手术切除的标准治疗失败。 齐留通已被证明是5-脂氧合酶活性的有效和选择性抑制剂。有证据表明，使用齐留通治疗的患者鼻部症状和息肉大小得到改善。 本研究的目的是比较齐留通和安慰剂治疗鼻息肉病的疗效。