EFFECT OF 5 LIPOXYGENASE INHIBITOR ON NASAL POLYPOSIS

鼻息肉疾病的病理生理机制复杂，病因难以捉摸。鼻息肉经常与哮喘、过敏性鼻炎和阿司匹林不耐受共存。主要由嗜酸性粒细胞组成的炎性浸润物是大多数鼻息肉的特征，无论其原因如何。标准的治疗方法是鼻腔局部使用类固醇，全身使用皮质类固醇，手术切除失败.齐留通已被证明是一种有效的和选择性的5-脂氧合酶活性抑制剂。已经有坊间观察到，接受齐留通治疗的患者的鼻部症状和息肉大小有所改善。本研究的目的是比较齐留通和安慰剂治疗鼻息肉疾病的疗效。

The pathophysiology of nasal polyp disease is complex and the etiology is elusive. Nasal polyps often coexist with asthma, allergic rhinitis and aspirin intolerance. An inflammatory infiltrate primarily composed of eosinophils is characteristic of the majority of nasal polyps regardless of the cause. Standard treatment with topical nasal steroids, systemic corticosteroids and surgical removal ofter fails. Zileuton has been shown to be a potent and selective inhibitor of 5-lipoxygenase activity. Improvement in nasal symptoms and polyp size in patients treated with zileuton has been anectdotally observed. The purpose of this study is to compare the efficacy of zileuton and placebo in nasal polyp disease.