12th Biennial Symposium of the International Eosinophil Society, Inc. (IES)

会议摘要 R13为即将举行的第12届两年一度的嗜酸性粒细胞研讨会“嗜酸性粒细胞2023”请求会议支持 2023年7月11日至15日，在加拿大安大略省汉密尔顿麦克马斯特大学大卫·布拉利健康科学中心举行 由国际嗜酸性粒细胞协会(IES)赞助。会议邀请了约35名受邀演讲者和 ~120名提交摘要的额外参与者。基础、翻译和临床的尖端计划 IES科学计划委员会正在与当地组织协商准备研究 委员会审议阶段。计划的会议包括：1)管制嗜酸性粒细胞的发展和贩运，2)在 肿瘤免疫学和癌症治疗，3)组织损伤/修复/器官疾病纤维化中的嗜酸性粒细胞，4) 嗜酸性粒细胞对局部免疫的调节以及与先天和适应性细胞的相互作用，5)细胞死亡(和应激， 自噬)在嗜酸性粒细胞生物学中，6)嗜酸性粒细胞与肠道微生物群之间的相互作用 动态平衡/生物失调，7)胃肠道疾病中的嗜酸性粒细胞，8)宿主防御中的嗜酸性粒细胞；抗细菌和病毒 回应包括新冠肺炎、皮肤病中的嗜酸性粒细胞、研究的新技术 嗜酸性粒细胞在健康和疾病中的作用；11)作为治疗靶点的嗜酸性粒细胞的现状和未来。这个 首要目标是为青少年之间的科学交流提供一个高度互动的跨学科论坛。 以及过敏学、免疫学、微生物学、血液学和癌症相关领域的知名科学家 嗜酸性粒细胞在健康和疾病中的作用。一个主要目标是将基础科学家与 嗜酸性粒细胞生物学方面的专业知识，以及对嗜酸性粒细胞相关疾病感兴趣的临床研究人员， 提高对疾病机制、嗜酸性粒细胞功能的意义的理解，并促进翻译 研究。第二个目标是促进年轻调查人员的发展和兴趣，以帮助支持他们的 事业发展，造就新一代“嗜酸性粒细胞”。这次会议有一个类似基石的结构 所有参与者都在一个会议地点进行无竞争的会议。科学和社会项目 强调为嗜酸性粒细胞科学家创建一个全球社区。这次会议特别及时，因为新的 直接或间接阻断嗜酸性粒细胞介导的发育的生物疗法的数据和批准 炎症途径现在提供了关于嗜酸性粒细胞在人类健康和健康中作用的明确发现 疾病。该研讨会非常强调跨学科研究，涵盖了全球重要的 疾病包括哮喘、嗜酸性食管炎、寄生虫病、高嗜酸性粒细胞综合征和新冠肺炎。 形式包括全体会议和海报会议，前者涵盖各国领导人在 该领域，然后是关于最近高影响力研究的前沿介绍，并有口头摘要介绍 整合到会议中。两个无人反对的海报会议包括对高影响力研究的简短介绍。 包括两个获奖讲座，埃利希奖表彰一位在 Gleich奖，授予前两年发表论文影响最大的科学家。

CONFERENCE ABSTRACT R13 conference support is requested for the 12th Biennial Eosinophil Symposium, “Eosinophils 2023”, to be held July 11-15, 2023 at the David Braley Health Sciences Centre, McMaster University, Hamilton, ON, Canada under the auspices of the International Eosinophil Society, Inc. (IES). The meeting hosts ~35 invited speakers and ~120 additional participants who submit abstracts. A cutting-edge program of basic, translational and clinical research is being prepared by the IES Scientific Program Committee in consultation with the Local Organizing Committee. Planned sessions include: 1) regulation of eosinophil development and trafficking, 2) eosinophils in tumor immunology and cancer therapy, 3) eosinophils in tissue injury/repair/fibrosis in organ disease, 4) eosinophil regulation of local immunity and interactions with innate and adaptive cells, 5) cell death (and stress, autophagy) in eosinophil biology, 6) reciprocal interactions between eosinophils and microbiomes in gut homeostasis/dysbiosis, 7) eosinophils in GI diseases, 8) eosinophils in host defense; anti-bacterial and viral responses including COVID-19, 9) eosinophils in dermatologic diseases, 10) novel technologies for studying eosinophils in health and disease, and 11) current status and future of eosinophils as therapeutic targets. The overarching goal is to provide a highly interactive, interdisciplinary forum for scientific exchange amongst junior and established scientists in the fields of allergy, immunology, microbiology, hematology, and cancer in relation to the eosinophil’s roles in health and disease. A primary objective is bringing together basic scientists with expertise in eosinophil biology, and clinician investigators interested in eosinophil-associated diseases, to improve understanding of disease mechanisms, significance of eosinophil functions, and foster translational research. A 2nd objective is to foster the development and interests of younger investigators to help support their career development, creating a new generation of “eosinophiles”. The meeting has a Keystone-like-structure with all participants in a single conference venue for unopposed sessions. Both the scientific and social programs emphasize creating a global community for eosinophil scientists. This meeting is particularly timely because new data and approvals of biologic therapies that directly or indirectly block eosinophil-mediated development and inflammatory pathways are now providing definitive findings on the roles of eosinophils in human health and disease. The symposium, with its strong emphasis on inter-disciplinary research, covers important global diseases including asthma, eosinophilic esophagitis, parasitoses, hypereosinophilic syndromes and COVID-19. The format includes plenary and poster sessions, with the former covering state-of-the-art topics by leaders in the field, followed by cutting edge presentations on recent high impact studies, with oral abstract presentations integrated into the sessions. Two unopposed poster sessions include short presentations of high-impact studies. Two prize lectures are included, the Ehrlich Award for a scientist who has made a major overall contribution to the field, and Gleich Award for a scientist with the highest impact publication over the previous two years.