DIABETES PREVENTION TRIAL--TYPE I DIABETES

糖尿病预防试验——I 型糖尿病

• 批准号: 6307451
• 负责人: WILLIAM L CLARKE
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307451
• 关键词: antigens; chemoprevention; clinical research; clinical trials; diabetes mellitus genetics; diabetes mellitus therapy; disease /disorder prevention /control; disease /disorder proneness /risk; family genetics; hormone therapy; human subject; human therapy evaluation; immunotherapy; insulin; insulin dependent diabetes mellitus; longitudinal human study

Relatives of IDDM's will be screened for ICA. ICA positive subjects will then be staged by IVGTT for risk. High risk subjects will be randomized to receive parenteral insulin therapy or no treatment and followed for 5 years to determine whether early intervention by antigen based therapy can delay the development of IDDM.

胰岛素依赖型糖尿病的亲属将接受伊卡筛查。 伊卡阳性受试者随后将通过IVGTT进行风险分期。 高风险受试者将随机接受肠外胰岛素治疗或不接受治疗，并随访5年，以确定通过基于抗原的治疗进行早期干预是否可以延迟IDDM的发展。