Novel PET imaging

新型 PET 成像

• 批准号: ST/K002937/1
• 负责人: Daniel Watts
• 金额: $ 11.03万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FK002937%2F1
• 关键词: Novel; PET; imaging

The work has the potential to produce significant improvements in the quality of positron emission tomography (PET) imaging. In PET imaging a patient is injected with sugar containing a radioactive atom, usually a flourine atom. When this atom decays 2 photons are emitted which come out in opposite directions back-to-back. By detecting many of these 2 photon events an image of the source can be reconstucted. PET imaging is used for many important clinical diagnoses such as identifying cancerous tissue and diagnosing alzheimers.This would allow smaller clinical features to be seen, permit earlier and more reliable diagnosis of disease and disease progression.We have developed a new technique which will improve the sharpness and contrast of the PET image. There will be significant costs benefits to this approach. Better imaging will lead to more appropriate treatment, resulting in fewer futile surgical interventions and improved therapy choices of the increasingly expensive chemotherapies applied by oncologists.Apart from Oncology applications, there is an increasing use of PET imaging in neurodegenerative disorders, such as Alzheimer's diseaseWe will work closely with Clinicians and PET physicists in our new Clinical Research Imaging Centre (CRIC) situated at the Edinburgh Royal Infirmary. Our new technique is a spin off from STFC funded research for fundamental nuclear physics.

这项工作有可能在正电子发射断层扫描（PET）成像质量方面产生重大改进。在PET成像中，患者被注射含有放射性原子的糖，通常是氟原子。当这个原子衰变时，发射出两个光子，它们背靠背地从相反的方向出来。通过检测这两个光子事件中的许多事件，可以重建源的图像。PET成像被用于许多重要的临床诊断，如识别癌组织和诊断阿尔茨海默病。这将允许看到更小的临床特征，允许更早和更可靠地诊断疾病和疾病进展。我们开发了一种新技术，将提高PET图像的清晰度和对比度。这种方法将带来巨大的成本效益。更好的成像将导致更合适的治疗，从而减少无效的外科干预，并改善肿瘤学家应用的日益昂贵的化疗的治疗选择。除了肿瘤学应用外，PET成像在神经退行性疾病中的应用越来越多，如阿尔茨海默病我们将与临床医生和PET物理学家在我们的新的临床研究成像中心（CRIC）密切合作位于爱丁堡皇家医院我们的新技术是STFC资助的基础核物理研究的衍生产品。

项目成果

Photon quantum entanglement in the MeV regime and its application in PET imaging.

• DOI: 10.1038/s41467-021-22907-5
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Watts DP;Bordes J;Brown JR;Cherlin A;Newton R;Allison J;Bashkanov M;Efthimiou N;Zachariou NA
• 通讯作者: Zachariou NA