Quantum Entanglement Tomography for enhanced medical imaging

用于增强医学成像的量子纠缠断层扫描

• 批准号: EP/P034276/2
• 负责人: Daniel Watts
• 金额: $ 18.01万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP034276%2F2
• 关键词: Quantum; Entanglement; Tomography; enhanced; medical

This project will enable the commercialisation of a new concept for positron imaging which utilises quantum entanglement - Quantum Entanglement Tomography (QET). The work will fund a new collaboration between the University of Edinburgh (UoE) and Kromek, one of the leading UK based manufacturers of particle detector products. The new collaboration has the potential to enable new high-quality and low-cost PET imaging detectors. In PET imaging a patient is injected with sugar containing a radioactive atom, usually a flourine atom. When this atom decays 2 photons are emitted which come out in opposite directions back-to-back. By detecting many of these 2 photon events an image of the source can be reconstucted. PET imaging is used for many important clinical diagnoses such as identifying cancerous tissue and diagnosing Alzheimer's disease. We (UoE) have developed and patented a new technique (QET) which will improve upon the sharpness and contrast of the PET image using quantum information. There will be significant cost benefits in adopting this approach. Better imaging will lead to more appropriate treatment, resulting in fewer futile surgical interventions and improved therapy choices for the increasingly expensive chemotherapies applied by oncologists. Apart from oncology applications, there is an increasing use of PET imaging in neurodegenerative disorders, such as Alzheimer's disease. This technical developments in this project would allow smaller and weaker clinical features to be seen, permitting earlier and more reliable diagnosis of disease and disease progression.The new quantum-information based medical imaging method will be commercialised with the CZT based detector systems developed by Kromek. These state-of-the-art photon detectors have close to ideal detection characteristics to accurately determine and exploit this quantum information.

该项目将使利用量子纠缠的正电子成像新概念-量子纠缠断层扫描（QET）商业化。这项工作将资助爱丁堡大学（UoE）和Kromek之间的新合作，Kromek是英国领先的粒子探测器产品制造商之一。新的合作有可能实现新的高质量和低成本的PET成像探测器。在PET成像中，患者被注射含有放射性原子的糖，通常是氟原子。当这个原子衰变时，发射出两个光子，它们背靠背地从相反的方向出来。通过检测这两个光子事件中的许多事件，可以重建源的图像。PET成像用于许多重要的临床诊断，例如识别癌组织和诊断阿尔茨海默病。我们（UoE）已经开发并获得了一项新技术（QET）的专利，该技术将使用量子信息提高PET图像的清晰度和对比度。采用这一方法将带来巨大的成本效益。更好的成像将导致更适当的治疗，从而减少无效的手术干预，并为肿瘤学家应用的日益昂贵的化疗提供更好的治疗选择。除了肿瘤学应用之外，PET成像在神经退行性疾病（例如阿尔茨海默病）中的使用越来越多。该项目中的技术发展将允许看到更小和更弱的临床特征，允许更早和更可靠地诊断疾病和疾病进展。新的基于量子信息的医学成像方法将与Kromek开发的基于CZT的探测器系统一起商业化。这些最先进的光子探测器具有接近理想的探测特性，可以准确地确定和利用这种量子信息。

项目成果

Photon quantum entanglement in the MeV regime and its application in PET imaging.

• DOI: 10.1038/s41467-021-22907-5
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Watts DP;Bordes J;Brown JR;Cherlin A;Newton R;Allison J;Bashkanov M;Efthimiou N;Zachariou NA
• 通讯作者: Zachariou NA