Meta-Analysis of Risk for Substance Use

药物使用风险的荟萃分析

• 批准号: 6361209
• 负责人: MARK W. LIPSEY
• 金额: $ 22.73万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6361209
• 关键词: age difference; aggression; alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; comorbidity; criminal behavior; disease /disorder proneness /risk; drug abuse information system; human data; longitudinal human study; marijuana abuse; meta analysis; social behavior disorders; statistics /biometry; substance abuse epidemiology; substance abuse related behavior; tobacco abuse; violence

This research concerns the development of substance use (alcohol, tobacco, or other drugs). One of the important empirical issues for this topic is identification of the risk factors during each age period that are associated with greater or lesser likelihood of subsequent substance use. No one study can cover all the risk variables, age periods, subject samples, and substance use outcomes that are of theoretical or practical importance, but advanced meta-analysis techniques can be used to conduct a detailed analysis and synthesis of empirical evidence across the full body of existing research. In a previous meta-analysis, data were coded from 1,557 reports of 215 longitudinal studies to generate a database of approximately 14,000 correlational effect sizes representing predictive relationships between risk variables and alcohol, tobacco, and drug use across a wide age range. The project proposed here will, first, update and extend that database to include recent research reports and to code correlations among risk variables and among outcome variables along with the risk- outcome correlations that were the focus of the earlier work. Second, further statistical analyses will be conducted to differentiate and synthesize the body of empirical research findings in relation to the following issues: 1. The categorization of antecedent risk variables into groups (factors) that are conceptually and empirically related to each other at different age periods. 2. The relative independent strength of association of the different categories of antecedent risk variables with subsequent substance use, and how those associations vary by life stage and type of substance used. Particular attention will be paid to the convergence of empirical data with theoretical formulations about associations between risk factors and substance use. 3. The comorbidity of substance use and other problem behaviors at various age periods, e.g., the extent of co-occurrence of substance use with aggressive behavior, crime, and mental illness. 4. The relationship of early tobacco, alcohol, or marijuana use (gateway drugs) to subsequent substance use and the related issue of age of onset of first substance use.

这项研究涉及物质使用（酒精，烟或其他药物）的发展。 该主题的重要经验问题之一是确定每个年龄段的风险因素，这些风险因素与随后的药物使用的可能性更大或更少。 没有一个研究可以涵盖理论或实际重要性的所有风险变量，年龄段，主题样本以及物质使用结果，但是可以使用先进的荟萃分析技术来进行详细的分析和整合现有研究的经验证据。在先前的荟萃分析中，数据从1,557个纵向研究的报告中进行了编码，以生成一个大约14,000个相关效应大小的数据库，这些数据库代表了风险变量与酒精，烟草，烟草和药物使用之间的预测关系，并且在广泛的年龄范围内。 首先，此处提出的项目将更新和扩展该数据库，以包括最新的研究报告以及风险变量之间以及结果变量之间的代码相关性以及风险结果相关性，这些风险相关性是早期工作的重点。其次，将进行进一步的统计分析，以区分和综合有关以下问题的经验研究结果的体系：1。将前提风险变量分为概念和经验上在不同年龄段上彼此之间相互关联的组（因素）分类。 2。不同类别的先行风险变量与随后的物质使用的相对独立强度，以及这些关联如何随寿命阶段和使用的物质类型而变化。 特别关注经验数据的融合以及有关风险因素与使用物质之间关联的理论表述。 3。在不同年龄时期，药物使用和其他问题行为的合并症，例如，侵略性行为，犯罪和精神疾病的物质使用的范围。 4。早期烟草，酒精或大麻（Gateway Drugs）与随后的物质使用以及首次使用初生时代的相关问题的关系。