ANTISOCIAL PERSONALITY AND ALCOHOL INDUCED AGGRESSION

反社会人格和酒精引起的攻击行为

基本信息

批准号：
2894118
负责人：
FREDERICK Gerard MOELLER
金额：
$ 14.11万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-01 至 2001-04-30
项目状态：
已结题

项目摘要

APPLICANT'S ABSTRACT: The overall aim of this proposal is to study alcohol induced aggression and attempt to determine the underlying neurochemistry of this behavior. Specific Aims: 1. To measure alcohol induced aggressive responding in subjects with Antisocial Personality Disorder (ASP and matched controls 2. To measure baseline serotonin function in subjects with ASP and matched controls using an ipsapiron neuroendocrine challenge. 3. To measure changes in alcohol induced aggressive responding in subjects with ASP after chronic administration of the serotonin reuptake inhibitor paroxetine compared to placebo. Rationale: The association between ethanol use and violence in the general population has been well documented (Lowenstein et al., 1990, Macdonald, 1961). Ethanol also increases aggressive responding in humans and animals under controlled laboratory conditions, but large inter-individual differences in this effect have been observed (Cherek et al., 1 984, Miczek et al., 1 993) Retrospective studies which examine the relationship between ethanol use and aggression find that alcoholics with Antisocial Personality Disorder (ASP) have an earlier age of onset of drinking, and more social and occupational problems related to drinking (Hesselbrock et al., 1984, Schuckit et al., 1985). These individuals have been found to have lower serotonin (5-HT) function as measured by CSF 5HIAA (Virkkunen et al., 1994). Thus there is evidence linking ASP and 5-HT to aggression and ethanol. The research proposed will investigate the relationship between ASP and ethanol induced aggressive responding and attempt to determine the role of 5-HT in these behaviors under controlled laboratory conditions.

申请人的摘要：该提案的总体目的是研究酒精诱发侵略并尝试确定的基本神经化学这种行为。具体目的： 1。测量酒精引起的侵略性反应反社会人格障碍（ASP和匹配对照 2。测量ASP受试者中的基线5-羟色胺功能并匹配使用iPSAPIROR神经内分泌挑战进行控制。 3。衡量酒精引起的受试者的侵略性反应的变化长期给药5-羟色胺再摄取抑制剂后的ASP 帕罗西汀与安慰剂相比。理由：乙醇使用与普通人群暴力之间的关联已经有充分的文献记载（Lowenstein等，1990，MacDonald，1961）。乙醇还增加了人类和动物的积极反应受控的实验室条件，但很大的个体差异已经观察到了这种效果（Cherek等，1 984，Miczek等，1 993）回顾性研究，研究乙醇使用与侵略性发现酗酒者患有反社会人格障碍（ASP）饮酒的发作年龄较早，更多的社会和职业与饮酒有关的问题（Hesselbrock等，1984，Schuckit等，， 1985）。这些人被发现具有较低的5-羟色胺（5-HT）通过CSF 5HIAA测量的功能（Virkkunen等，1994）。因此有将ASP和5-HT与侵略性和乙醇联系起来的证据。研究拟议的将研究ASP和乙醇诱导的关系积极反应并试图确定5-HT在这些中的作用受控实验室条件下的行为。