Do NK cells limit the long term burden of CMV in older Australians and transplant recipients?

NK 细胞是否会限制澳大利亚老年人和移植受者的 CMV 长期负担？

• 批准号: nhmrc : 1068652
• 负责人: A/Pr Campbell Witt
• 金额: $ 27.6万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nk-cells-limit-transplant-recipients/455352
• 关键词: Do; NK; cells; limit; long

Most people are infected with cytomegalovirus at an early age. The virus is not naturally cleared from the body but becomes latent and may be reactivated by stress or inflammation. Repeated immune responses to these reactivations causes more inflammation and wears out the immune system resulting in diseases of aging (eg: cardiovascular disease). Here we investigate which aspects of the immune system can control CMV in healthy people and in renal transplant recipients. We focus on a population of cells called natural killer (NK) cells.

大多数人在很小的时候就感染了巨细胞病毒。病毒不会自然地从体内清除，但会潜伏，并可能因应激或炎症而重新激活。对这些重新激活的重复免疫反应会导致更多的炎症和免疫系统的磨损，从而导致衰老疾病(例如：心血管疾病)。在这里，我们调查免疫系统的哪些方面可以控制健康人和肾移植受者的CMV。我们关注的是一种称为自然杀伤(NK)细胞的细胞群。