Stimulation of human immunodeficiency virus type 1 (HIV-1) specific cytolytic effector function using allogeneic cell immunotherapy

目前还没有预防性的艾滋病毒疫苗。刺激人体自身的免疫细胞(T细胞)可能与更好地抵御病毒有关，我们最近发现，人类已存在的T细胞经常受到外来(同种)细胞的刺激。因此，我们的目标是确定“接种”同种异体细胞是否能刺激人类体内的HIV特异性免疫反应。这些结果可能会对艾滋病毒疫苗的设计产生重要影响。

A preventative HIV vaccine is not currently available. Stimulation of the bodies own immune cells (T-cells) may be associated with better protection against the virus, and we have recently discovered that T-cells already present in humans are frequently stimulated by foreign (allogeneic) cells. Therefore we aim to determine if “vaccination” with allogeneic cells could stimulate a HIV specific immune response in humans. These results could have important implications for HIV vaccine design.