Stimulation of human immunodeficiency virus type 1 (HIV-1) specific cytolytic effector function using allogeneic cell immunotherapy

使用同种异体细胞免疫疗法刺激人类免疫缺陷病毒 1 型 (HIV-1) 特异性溶细胞效应功能

• 批准号: nhmrc : 1034858
• 负责人: A/Pr Campbell Witt
• 金额: $ 25.18万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stimulation-human-immunodeficiency-cell-immunotherapy/110939
• 关键词: Stimulation; human; immunodeficiency; virus; type

A preventative HIV vaccine is not currently available. Stimulation of the bodies own immune cells (T-cells) may be associated with better protection against the virus, and we have recently discovered that T-cells already present in humans are frequently stimulated by foreign (allogeneic) cells. Therefore we aim to determine if “vaccination” with allogeneic cells could stimulate a HIV specific immune response in humans. These results could have important implications for HIV vaccine design.

目前还没有预防性的艾滋病毒疫苗。刺激人体自身的免疫细胞(T细胞)可能与更好地抵御病毒有关，我们最近发现，人类已存在的T细胞经常受到外来(同种)细胞的刺激。因此，我们的目标是确定“接种”同种异体细胞是否能刺激人类体内的HIV特异性免疫反应。这些结果可能会对艾滋病毒疫苗的设计产生重要影响。