Role of NK Receptors in susceptibility and resistance to human malaria

NK 受体在人类疟疾易感性和抵抗力中的作用

• 批准号: nhmrc : 516735
• 负责人: A/Pr Campbell Witt
• 金额: $ 36.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nk-receptors-human-malaria/101264
• 关键词: Role; NK; Receptors; susceptibility; resistance

Malaria kills 2 million children every year. However, many eventually become resistant to the disease. What causes some kids to die, and how others become resistant, is unknown. We believe that genes for Natural Killer molecules in the immune system can protect people against malaria, but can also over-react in the wrong way and make things worse. We plan to investigate the role of Natural Killer genes in causing disease and also protecting in young children in Papua New Guinea against malaria.

每年有200万儿童死于疟疾。然而，许多人最终对这种疾病产生了抵抗力。是什么原因导致一些孩子死亡，以及其他人如何成为耐药，是未知的。我们认为，免疫系统中的自然杀伤分子基因可以保护人们免受疟疾的侵害，但也可能以错误的方式过度反应，使情况变得更糟。我们计划调查自然杀伤基因在引起疾病和保护巴布亚新几内亚幼儿免受疟疾侵害中的作用。