INTERMEDIATE BIOMARKERS FOR COLORECTAL CANCER & MELANOMA

结直肠癌的中间生物标志物

• 批准号: 6356784
• 负责人: Martin Lipkin
• 金额: $ 15.53万
• 依托单位: STRANG CANCER PREVENTION CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356784
• 关键词: apoptosis; biomarker; cancer prevention; carcinogenesis inhibitor; cell proliferation; chemoprevention; colorectal neoplasms; disease /disorder model; drug screening /evaluation; fatty acid metabolism; genetically modified animals; histopathology; laboratory mouse; linoleate; melanoma; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplastic process

This study characterizes and establishes intermediate biomarkers for two transgenic mouse models which mimic genetic alterations intimately linked to the development of human cancer (e.g. MSH1/APC1638 and P16/Ha Ras transgenic mouse models). Such studies include gross and microscopic pathology examining tumor development, measurements of cell proliferation and apoptosis. These studies have the goal of standardizing these genetically relevant transgenic models and characterizing these models highly relevant to humans for further chemoprevention studies. The goal of the study is to evaluate the modulating effects of selected chemopreventive agents on linoleic acid metabolism and to validate these effects against ultimate cancer incidence and multiplicity in the colon.

本研究表征并建立了以下中间生物标志物： 两种模拟基因改变的转基因小鼠模型 与人类癌症的发展密切相关（例如， MSH 1/APC 1638和P16/Ha Ras转基因小鼠模型）。 此类研究 包括检查肿瘤发展大体和显微病理学， 细胞增殖和凋亡的测量。这些研究 标准化这些基因相关转基因的目标， 模型，并将这些模型与人类高度相关， 进一步的化学预防研究。 本研究的目的是评估 选择的化学预防剂对亚油酸代谢的影响， 验证这些对最终癌症发病率的影响， 结肠的多样性。

项目成果

Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice.

吡罗昔康增加 Mlh1 /- /Apc1638(N/ ) 小鼠的结肠肿瘤发生并促进细胞凋亡。

• 发表时间: 2007
• 期刊: Anticancer research
• 影响因子: 2
• 作者: Palmerini,Emanuela;Fan,Kunhua;Yang,Kan;Risio,Mauro;Edelmann,Winfried;Lipkin,Martin;Biasco,Guido
• 通讯作者: Biasco,Guido