INTERMEDIATE BIOMARKERS FOR COLORECTAL CANCER & MELANOMA

本研究表征并建立了中间生物标志物 两种模拟基因改变的转基因小鼠模型 与人类癌症的发展密切相关（例如 MSH1/APC1638 和 P16/Ha Ras 转基因小鼠模型）。 此类研究 包括检查肿瘤发展的大体和微观病理学， 细胞增殖和凋亡的测量。这些研究有 标准化这些与遗传相关的转基因的目标 模型并表征这些模型与人类高度相关 进一步的化学预防研究。 该研究的目的是评估调节作用 选择对亚油酸代谢有影响的化学预防剂 验证这些对最终癌症发病率的影响， 结肠中的多重性。

This study characterizes and establishes intermediate biomarkers for two transgenic mouse models which mimic genetic alterations intimately linked to the development of human cancer (e.g. MSH1/APC1638 and P16/Ha Ras transgenic mouse models). Such studies include gross and microscopic pathology examining tumor development, measurements of cell proliferation and apoptosis. These studies have the goal of standardizing these genetically relevant transgenic models and characterizing these models highly relevant to humans for further chemoprevention studies. The goal of the study is to evaluate the modulating effects of selected chemopreventive agents on linoleic acid metabolism and to validate these effects against ultimate cancer incidence and multiplicity in the colon.