CORE--INSTRUMENTATION/SUPPORT FACILITY

CORE设施旨在为所有或大多数项目参与者使用的几个技术领域提供支持。它提供核磁共振光谱功能，方便访问500、600和800 MHz仪器，使用Beckman XL-I超离心机进行分析超离心，傅里叶变换红外光谱，肽合成和计算能力，包括三维结构显示，使用分子动力学模拟建模和数据库搜索。自两年多前开始赠款以来，这些设施中的每一个都已建立并投入运作。虽然要求进行一些理想的升级，但人们认为核心已经基本发展到一个优秀的状态，如果配备适当的人员，完全有能力支持下一个拨款期提出的研究。

The CORE facility is designed to provide support in several technical areas used by all or most of the participants in the program. It offers capabilities in NMR spectroscopy with facilitated access to 500, 600, and 800 MHz instruments, analytical ultracentrifugation using the Beckman XL-I ultracentrifuge, Fourier transform infrared spectroscopy, peptide synthesis, and computational capabilities that include three dimensional structural displays, modeling using molecular dynamics simulation, and database searching. In the period since the initiation of the grant a little more than two years ago, each of these facilities has been created and brought to operational status. While some desirable upgrades are requested, it is felt that the CORE has basically evolved to an excellent state, fully capable of supporting the research proposed for the next grant period if it is appropriately staffed.