CORE--MOLECULAR BIOLOGY CORE FACILITY

分子生物学核心设施的目的是提供 为调查人员提供材料、工具和专业知识， 开展利用分子生物学技术的研究。 核心 主任，博士雅典娜Andreadis将指导这项服务的帮助下， 有经验的技术员。 所有获资助的项目均会使用 设施。 Jungalwala博士将与Andreadis博士合作 并对GlcNAc-转移酶和SGGL-1结合凝集素的基因进行测序。 博士麦克卢尔和史密斯博士将使用该设施进行研究， 岩藻糖基转移酶基因麦卡弗里博士会用这个设备 并对编码乙醛脱氢酶的人类基因进行测序 参与视黄酸的生物合成。 安德烈迪斯医生计划 筛选克隆和序列基因与轴突特异性 tau转录物和蛋白质。 建造这个核心设施需要时间- 高效和成本效益的方式来实现该计划的目标。

The purpose of the Molecular Biology Core Facility is to provide the program investigators with the materials, instruments and expertise to carry out research that utilizes molecular biology techniques. The Core Director, Dr. Athena Andreadis will guide this service with the help of an experienced technician. All projects in the grant will use the facility. Dr. Jungalwala will collaborate with Dr. Andreadis to clone and sequence the genes for GlcNAc-transferase and SGGL-1 binding lectins. Dr. McCluer and Dr. Smith will use the facility for the studies on fucosyltransferase genes.Dr. McCaffery will use the facility to isolate and sequence the human gene that encodes the aldehyde dehydrogenase involved in the biosynthesis of retinoic acid. Dr. Andreadis plans to screen for clones and sequence genes interacting with the axonal specific tau transcript and protein. Generating this core facility is a time- efficient and cost-effective way to achieve the goals of the program.