CORE--MOLECULAR BIOLOGY CORE FACILITY

分子生物学核心设施的目的是提供 拥有材料、仪器和专业知识的计划调查人员 开展利用分子生物学技术的研究。《核心》 主任，雅典娜·安德烈亚迪斯博士将在 一位经验丰富的技术员。拨款中的所有项目都将使用 设施。Jungalwala博士将与Andreadis博士合作进行克隆 并对GlcNAc转移酶和SGGL-1结合凝集素基因进行测序。 McCluer博士和Smith博士将使用该设备进行关于 岩藻糖基转移酶基因。麦卡弗里将利用该设施隔离 并对编码乙醛脱氢酶的人类基因进行测序 参与维甲酸的生物合成。安德烈亚迪斯博士计划 筛选与轴突特异性相互作用的克隆和序列基因 Tau转录本和蛋白质。建造这个核心设施是一段时间- 以高效率和高成本效益的方式实现方案的目标。

The purpose of the Molecular Biology Core Facility is to provide the program investigators with the materials, instruments and expertise to carry out research that utilizes molecular biology techniques. The Core Director, Dr. Athena Andreadis will guide this service with the help of an experienced technician. All projects in the grant will use the facility. Dr. Jungalwala will collaborate with Dr. Andreadis to clone and sequence the genes for GlcNAc-transferase and SGGL-1 binding lectins. Dr. McCluer and Dr. Smith will use the facility for the studies on fucosyltransferase genes.Dr. McCaffery will use the facility to isolate and sequence the human gene that encodes the aldehyde dehydrogenase involved in the biosynthesis of retinoic acid. Dr. Andreadis plans to screen for clones and sequence genes interacting with the axonal specific tau transcript and protein. Generating this core facility is a time- efficient and cost-effective way to achieve the goals of the program.