ROLE OF MILK BORNE HORMONES FOR THE SUCKLING
ROLE OF MILK BORNE HORMONES FOR THE SUCKLING
批准号:
6181993
负责人:
ROBERT S MCCUSKEY
金额:
$80.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-09-30 至 2002-06-30
中文摘要
需要计划项目支持,以进行协调、多学科的
研究乳源性激素和其他活性物质作用的方法
新生儿的生物物质。请求为三个人提供支持
科学项目和三个核心(形态、动物和
管理)。三个拟议的项目涉及命运和
乳源性多肽激素和肉碱对哺乳大鼠的影响。
它们是:
项目1.乳源生长因子在哺乳中的作用:
它们的内容和合成。首席调查员:O·科尔多夫斯基
项目2.乳源生长因子在哺乳中的作用:
它们对新生儿的影响。主要调查者:A.F.菲利普斯
项目3.乳源性生物物质在发育过程中的作用
肝脏。首席调查员:R.McCuskey
这些项目本质上是基本的,从它们获得的信息
将适用于各种正常和病理情况。
研究表明,这些物质中的一些在
婴儿配方奶粉,但存在于人类母乳中,强调
提出这些研究的重要意义。
英文摘要
Program Project support is requested for a coordinated, multidisciplinary
approach to investigate the role of milk-borne hormones and other active
biological substances for the neonate. Support is requested for three
scientific projects and three cores (Morphological, Animal and
Administrative). The three proposed projects deal with the fate and
effects of milk-borne peptide hormones and carnitine in the suckling rat.
They are:
PROJECT 1. Role of Milk-Borne Growth Factors for the Suckling:
Their Content and Synthesis. Principal Investigator: O. Koldovsky
PROJECT 2. Role of Milk-Borne Growth Factors for the Suckling:
Their Effects on the Neonate. Principal Investigator: A.F. Philipps
PROJECT 3. Role of Milk-Borne Biological Substances in the Developing
Liver. Principal Investigator: R. McCuskey
These projects are basic in nature, and the information derived from them
will be applicable to a variety of normal and pathological conditions.
Studies have demonstrated that some of these substances are absent in
infant formulas, but are present in human breast milk, emphasizing the
important significance of these proposed studies.
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Rat milk decreases necrotizing enterocolitis in a rat model.
大鼠奶可降低大鼠模型中的坏死性小肠结肠炎。
DOI:
10.1007/978-1-4757-4242-8_67
发表时间:
2004
期刊:
Advances in experimental medicine and biology
影响因子:
--
作者:
[Dvorak,Bohuslav, Halpern,MelissaD, Holubec,Hana, Dvorakova,Katerina, Dominguez,JessicaA, Williams,CatherineS, Meza,YolandaG]
通讯作者:
Meza,YolandaG
DOI:
10.1016/0024-3205(92)90161-h
发表时间:
1992
期刊:
Life sciences
影响因子:
6.1
作者:
[T. Gillespie;P. Konings;B. J. Merrill;T. Davis]
通讯作者:
T. Gillespie;P. Konings;B. J. Merrill;T. Davis
DOI:
10.1097/00005176-199802000-00012
发表时间:
1998-02
期刊:
Journal of pediatric gastroenterology and nutrition
影响因子:
2.9
作者:
[R. Rao;A. Philipps;Catherine S. Williams;David M. McCracken;O. Koldovský]
通讯作者:
R. Rao;A. Philipps;Catherine S. Williams;David M. McCracken;O. Koldovský
DOI:
10.1016/s0167-0115(00)00216-0
发表时间:
2001
期刊:
Regulatory peptides
影响因子:
--
作者:
[Fellah,AM, Philipps,AF, Gillespie,TJ, Galo,JR, Dvorák,B]
通讯作者:
Dvorák,B
Hepatic microvascular development in relation to the morphogenesis of hepatocellular plates in neonatal rats.
新生大鼠肝微血管发育与肝细胞板形态发生的关系。
DOI:
10.1002/ar.a.10117
发表时间:
2003
期刊:
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.
影响因子:
--
作者:
[McCuskey,RobertS, Ekataksin,Wichai, LeBouton,AlbertV, Nishida,Jiro, McCuskey,MargaretK, McDonnell,Deboragh, Williams,Catherine, Bethea,NancyW, Dvorak,Bohuslav, Koldovsky,Otakar]
通讯作者:
Koldovsky,Otakar
共 22 条
Aging and Hepatic Microvascular Dysfunction
-
批准号:7104091
-
项目类别:
-
资助金额:$15.64万
-
财政年份:2006
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
Aging and Hepatic Microvascular Dysfunction
-
批准号:7244112
-
项目类别:
-
资助金额:$11.17万
-
财政年份:2006
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
-
批准号:6509052
-
项目类别:
-
资助金额:$30.3万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
-
批准号:6629507
-
项目类别:
-
资助金额:$30.3万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK-BORNE SUBSTANCES IN DEVELOPING LIVER
-
批准号:6341013
-
项目类别:
-
资助金额:$14.55万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
-
批准号:6752953
-
项目类别:
-
资助金额:$30.3万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
-
批准号:6371589
-
项目类别:
-
资助金额:$30.3万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
PHILIPS XL30 SCANNING ELECTRON MICROSCOPE
-
批准号:6052084
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
-
批准号:6196782
-
项目类别:
-
资助金额:$29.75万
-
财政年份:2000
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK-BORNE SUBSTANCES IN DEVELOPING LIVER
-
批准号:6202071
-
项目类别:
-
资助金额:$14.55万
-
财政年份:1999
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK-BORNE SUBSTANCES IN DEVELOPING LIVER
-
批准号:6108544
-
项目类别:
-
资助金额:$14.55万
-
财政年份:1998
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK-BORNE SUBSTANCES IN DEVELOPING LIVER
-
批准号:6241097
-
项目类别:
-
资助金额:$13.9万
-
财政年份:1997
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK BORNE HORMONES FOR THE SUCKLING
-
批准号:2888988
-
项目类别:
-
资助金额:$77.93万
-
财政年份:1991
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3522533
-
项目类别:
-
资助金额:$2.05万
-
财政年份:1991
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ELECTRON MICROSCOPE FACILITY
-
批准号:3520228
-
项目类别:
-
资助金额:$33.7万
-
财政年份:1989
-
负责人:ROBERT S MCCUSKEY
-
依托单位:
ROLE OF MILK-BORNE SUBSTANCES IN DEVELOPING LIVER
-
批准号:5212725
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:ROBERT S MCCUSKEY
-
依托单位:--