A novel approach to restoration of tumour suppression in lung cancer

恢复肺癌肿瘤抑制的新方法

• 批准号: nhmrc : 1063389
• 负责人: A/Pr Gavin Wright
• 金额: $ 39.91万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-approach-restoration-lung-cancer/455053
• 关键词: novel; approach; restoration; tumour; suppression

Loss of a tumour suppressor is a key event in every cancer, including lung cancer. Therefore restoration of the expression and/or activity of the tumour suppressor is an attractive approach to anti-cancer treatment. In order to restore tumour suppression, a detailed understanding of the mechanism by which a given tumour suppressor is regulated is required. This application focuses on our discovery of a novel mechanism by which a key tumour suppressor of lung cancer is regulated.

肿瘤抑制基因的缺失是包括肺癌在内的所有癌症的关键事件。因此，恢复肿瘤抑制基因的表达和/或活性是一种有吸引力的抗癌治疗方法。为了恢复肿瘤抑制，需要详细了解给定的肿瘤抑制因子被调控的机制。这项申请的重点是我们发现了一种新的机制，通过这种机制来调控肺癌的关键肿瘤抑制因子。