LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES

肺部成像：超极化稀有气体 MRI

• 批准号: 6349312
• 负责人: IVAN E DIMITROV
• 金额: $ 4.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349312
• 关键词: alternative medicine; bioimaging /biomedical imaging; biomedical resource; liver; magnetic resonance imaging; medical rehabilitation related tag; nervous system; pain; rehabilitation; skeletal system; technology /technique

This study is an exploration of the human brain processing of pain using functional MRI on humans. The goal is to develop objective quantitative assay of pain. The subjects will be patients with a specific type of pain, postherpetic neuralgia, an aftermath of herpes zoster. Such patients have pain is localized to the nerve affected by the herpes zoster and is always unilateral. The severity of the pain increases greatly when the localized area of the nerve is touched with external stimuli such as brushing. We will examine brain activation pattern in response to painful stimulation. Stimulation on contralateral non-painful site will be used as control. Normal subjects will also serve as controls. A stimulating apparatus for use in magnet bore has been constructed, which allows a mechanical stimulus on patient body surface area with a controlled amount of force. We are starting to collect data with the exerted force varied, and oberve the change in intensity in the brain images.

这项研究是对人类大脑处理疼痛的探索