LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES

这项研究是对人类大脑处理疼痛的一种探索 在人类身上使用功能性核磁共振。目标是制定目标 疼痛的定量测定。受试者将是患有 特定类型的疼痛，带状疱疹后遗神经痛，疱疹后遗症 带状疱疹。这类患者的疼痛是局限于神经受影响的 带状疱疹总是单侧的。疼痛的严重程度 当神经的局部区域接触到 外部刺激，如刷牙。我们将检查大脑的激活情况 对痛苦刺激的反应模式。刺激开启 以对侧非痛性部位作为对照。正常 受试者也将作为对照。 一种用于磁体钻孔的刺激装置已经被 构造，允许对患者身体进行机械刺激 有控制力的表面积。我们开始 收集不同受力情况下的数据，并观察其变化 脑部图像中的强度。

This study is an exploration of the human brain processing of pain using functional MRI on humans. The goal is to develop objective quantitative assay of pain. The subjects will be patients with a specific type of pain, postherpetic neuralgia, an aftermath of herpes zoster. Such patients have pain is localized to the nerve affected by the herpes zoster and is always unilateral. The severity of the pain increases greatly when the localized area of the nerve is touched with external stimuli such as brushing. We will examine brain activation pattern in response to painful stimulation. Stimulation on contralateral non-painful site will be used as control. Normal subjects will also serve as controls. A stimulating apparatus for use in magnet bore has been constructed, which allows a mechanical stimulus on patient body surface area with a controlled amount of force. We are starting to collect data with the exerted force varied, and oberve the change in intensity in the brain images.