Chemical Exchange Saturation Transfer (CEST) MRI for the Characterization Small Renal Masses
用于表征小肾脏肿块的化学交换饱和转移 (CEST) MRI
基本信息
- 批准号:10406271
- 负责人:
- 金额:$ 41.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-17 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AbdomenAblationAcademiaAccelerationAccountingAddressAdoptedAlgorithmsBenignBiological MarkersBiopsyChemicalsClear cell renal cell carcinomaClinicalClinical Assessment ToolClinical ResearchCollaborationsComplicationContrast MediaDepositionDetectionDevelopmentDiagnosisEarly DiagnosisElementsEvaluationExposure toFatty acid glycerol estersGlycogenGoalsHistologicHistologyHistopathologyHumanImageImaging DeviceImaging technologyImmunohistochemistryIncidenceIndolentIndustryInjectionsKidneyKnowledgeMagnetic Resonance ImagingMalignant - descriptorMalignant NeoplasmsMapsMeasurementMedical centerMetabolicMethodologyMethodsMolecularMorbidity - disease rateMotionNorth AmericaOncologyOperative Surgical ProceduresOxyphilic AdenomaPatient-Focused OutcomesPatientsPerfusionPredictive ValueProceduresPrognosisProtocols documentationPublicationsRenal Cell CarcinomaRenal MassRenal carcinomaReportingResearchResearch PersonnelResolutionRoleScientistSignal TransductionSpecialized Program of Research ExcellenceSpectrum AnalysisStratificationStructureTechniquesTechnologyTechnology TransferTexasTissuesTranslatingTranslationsUniversitiesWomananatomic imagingbasebreast lesionclinical centerclinical translationcohortimaging modalityimaging systemimprovedin vivoindustry partnerkidney imagingmenmortalityneuro-oncologynon-invasive imagingnovelovertreatmentpreclinical studypredictive markerprogramspsychologicrecruitrespiratoryrisk stratificationsoft tissuesuccesstooltumortumor microenvironmentvirtual biopsy
项目摘要
Project Summary
An Academic-Industrial partnership between scientists and clinicians at the University of Texas Southwestern
(UTSW) Medical Center and Philips Research Hamburg and Philips North America (Philips) has been formed
with the purpose of translating the novel molecular MR imaging method, Chemical Exchange Saturation
Transfer (CEST), into a clinical tool for the assessment of Small Renal Masses (SRMs). CEST has already
demonstrated feasibility in neurooncology applications. The management of SRMs is challenging because a
substantial number of them are benign or indolent malignant tumors, leading to patient exposure to
unnecessary morbidity from biopsies and surgery. Non-invasive distinction between benign/indolent tumors
and aggressive tumors would allow for better risk stratification and patient management. While novel, CEST
has already been adopted by certain clinical centers for assessment in neuro oncology. Recently, our group
demonstrated the promise of CEST to the characterization of breast lesions. Here, we propose to broaden the
application of CEST to renal oncology by addressing the inherent challenges of application of CEST in the
abdomen and by optimizing CEST in patients with SRMs.
Our hypothesis is that technical development of CEST-MRI allows observation of aggressive tumor
microenvironment in SRM. Our goal is to advance CEST methodology to become a part of comprehensive SRM
evaluation protocol. The goals of the project will be achieved via the following Specific Aims:
Aim 1: To develop and optimize CEST methodology for SRMs on 3T human MRI system.
This is technical development Aim, where we will evaluate several approaches addressing major issues
associated with translation of CEST to kidney oncology applications: (i) improved resolution and fat separation,
(ii) acceleration of acquisition using pseudo-cartesian and undersampled algorithms,(iii) motion correction and
(iv) advanced Z-spectrum analysis methods.
Aim 2: To evaluate the optimized CEST-MRI as a predictive biomarker of SRM hystology.
The Aim's focus in on the translation of the CEST technology to SRM patients: (i) evaluation of the optimized
in a group of SRM patients: (ii) correlation of the CEST-MRI measurements with histopathology results and
correlation of CEST-MRI with glycogen deposition.
项目摘要
德克萨斯大学西南分校科学家和临床医生之间的学术-工业合作伙伴关系
(UTSW)医疗中心和飞利浦汉堡研究所以及飞利浦北美(Philips)已经成立
目的是将新的分子MR成像方法,化学交换饱和,
转移(CEST),成为评估小肾脏肿块(SRM)的临床工具。CEST已经
在神经肿瘤学应用中证明了可行性。供应商关系管理具有挑战性,因为
其中相当多的是良性或惰性恶性肿瘤,导致患者暴露于
活检和手术造成不必要的发病率。良性/惰性肿瘤之间的非侵入性区分
而侵袭性肿瘤将允许更好的风险分层和患者管理。虽然小说,CEST
已经被某些临床中心用于神经肿瘤学的评估。最近,我们集团
证明了CEST对乳腺病变定性的前景。在这里,我们建议扩大
通过解决CEST在肾肿瘤学中应用的固有挑战,
腹部和优化CEST在SRMs患者。
我们的假设是CEST-MRI的技术发展允许观察侵袭性肿瘤
SRM中的微环境。我们的目标是推进CEST方法,使其成为全面SRM的一部分
评估协议。该项目的目标将通过以下具体目标实现:
目的1:在3 T人体MRI系统上开发和优化SRMs的CEST方法。
这是技术发展目标,我们将评估解决主要问题的几种方法
与CEST向肾肿瘤学应用的转化相关:(i)改善的分辨率和脂肪分离,
(ii)使用伪载波和欠采样算法的采集加速,(iii)运动校正,以及
(iv)先进的Z谱分析方法。
目的2:评价优化的CEST-MRI作为SRM组织学预测生物标志物的价值。
目的的重点是将CEST技术转化为SRM患者:(i)评价优化的
在一组SRM患者中:(ii)CEST-MRI测量与组织病理学结果的相关性,
CEST-MRI与糖原沉积的相关性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
IVAN E DIMITROV其他文献
IVAN E DIMITROV的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('IVAN E DIMITROV', 18)}}的其他基金
Chemical Exchange Saturation Transfer (CEST) MRI for the Characterization Small Renal Masses
用于表征小肾脏肿块的化学交换饱和转移 (CEST) MRI
- 批准号:
10611440 - 财政年份:2021
- 资助金额:
$ 41.36万 - 项目类别:
Chemical Exchange Saturation Transfer (CEST) MRI for the Characterization Small Renal Masses
用于表征小肾脏肿块的化学交换饱和转移 (CEST) MRI
- 批准号:
10209989 - 财政年份:2021
- 资助金额:
$ 41.36万 - 项目类别:
Method for measuring ventilation-perfusion mismatches
测量通气-灌注不匹配的方法
- 批准号:
6810219 - 财政年份:2004
- 资助金额:
$ 41.36万 - 项目类别:
LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES
肺部成像:超极化稀有气体 MRI
- 批准号:
6657646 - 财政年份:2002
- 资助金额:
$ 41.36万 - 项目类别:
LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES
肺部成像:超极化稀有气体 MRI
- 批准号:
6495455 - 财政年份:2001
- 资助金额:
$ 41.36万 - 项目类别:
LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES
肺部成像:超极化稀有气体 MRI
- 批准号:
6349312 - 财政年份:2000
- 资助金额:
$ 41.36万 - 项目类别:
相似海外基金
Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly
利用超分子自组装靶向消融脑动脉粥样硬化
- 批准号:
24K21101 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
心房細動に対するPulsed Field Ablationの組織創傷治癒過程を明らかにする網羅的研究
阐明房颤脉冲场消融组织伤口愈合过程的综合研究
- 批准号:
24K11201 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
遅延造影心臓MRIによる心房細動Ablation冷却効果の比較:28 vs. 31 mm Cryoballoon
使用延迟对比增强心脏 MRI 比较房颤消融冷却效果:28 毫米与 31 毫米 Cryoballoon
- 批准号:
24K11281 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
InSPACE-VT_Development and Validation of Virtual Pace Mapping to Guide Catheter Ablation of Ventricular Tachycardia
InSPACE-VT_虚拟起搏测绘的开发和验证以指导室性心动过速导管消融
- 批准号:
EP/Z001145/1 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Fellowship
CAREER: Heat Penetration Depth and Direction Control with Closed-Loop Device for Precision Ablation
职业:利用闭环装置控制热穿透深度和方向,实现精确烧蚀
- 批准号:
2338890 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334777 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334775 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334776 - 财政年份:2024
- 资助金额:
$ 41.36万 - 项目类别:
Continuing Grant
Cryo laser-ablation system (157+193nm) with 'triple-quad' plasma mass spectrometer, Cryo-LA-ICPMS/MS
带有“三重四极杆”等离子体质谱仪、Cryo-LA-ICPMS/MS 的冷冻激光烧蚀系统 (157 193nm)
- 批准号:
515081333 - 财政年份:2023
- 资助金额:
$ 41.36万 - 项目类别:
Major Research Instrumentation
MRI: Acquisition of a Laser Ablation - Inductively Coupled Plasma - Triple Quadrupole - Mass Spectrometer (LA-ICP-QQQ-MS) System For Research and Education
MRI:获取用于研究和教育的激光烧蚀 - 电感耦合等离子体 - 三重四极杆 - 质谱仪 (LA-ICP-MS/MS) 系统
- 批准号:
2320040 - 财政年份:2023
- 资助金额:
$ 41.36万 - 项目类别:
Standard Grant